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Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.
Chen W, Yang KB, Zhang YZ, Lin ZS, Chen JW, Qi SF, Wu CF, Feng GK, Yang DJ, Chen M, Zhu XF, Li X. Chen W, et al. Among authors: feng gk. J Exp Clin Cancer Res. 2024 Aug 30;43(1):248. doi: 10.1186/s13046-024-03168-8. J Exp Clin Cancer Res. 2024. PMID: 39215364 Free PMC article.
Inactivated cGAS-STING Signaling Facilitates Endocrine Resistance by Forming a Positive Feedback Loop with AKT Kinase in ER+HER2- Breast Cancer.
Zhang KM, Zhao DC, Li ZY, Wang Y, Liu JN, Du T, Zhou L, Chen YH, Yu QC, Chen QS, Cai RZ, Zhao ZX, Shan JL, Hu BX, Zhang HL, Feng GK, Zhu XF, Tang J, Deng R. Zhang KM, et al. Among authors: feng gk. Adv Sci (Weinh). 2024 Sep;11(35):e2403592. doi: 10.1002/advs.202403592. Epub 2024 Jul 18. Adv Sci (Weinh). 2024. PMID: 39023171 Free PMC article.
A pan-KRAS degrader for the treatment of KRAS-mutant cancers.
Yang J, Wang QL, Wang GN, Ye JC, Li ZQ, Wang JY, Liang ZH, Li SX, Sun C, Liao WT, Gao YJ, Wang J, Mao Y, Yu C, Feng GK, Zeng MS. Yang J, et al. Among authors: feng gk. Cell Discov. 2024 Jun 28;10(1):70. doi: 10.1038/s41421-024-00699-4. Cell Discov. 2024. PMID: 38937452 Free PMC article.
112 results