Reynolds KA - Search Results

1

Application of a newly identified and characterized 18-o-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins.

Ghatge MS, Palaniappan N, Alhamadsheh MM, DiBari J, Reynolds KA. Ghatge MS, et al. Among authors: reynolds ka. Appl Environ Microbiol. 2009 Jun;75(11):3469-76. doi: 10.1128/AEM.02590-08. Epub 2009 Mar 20. Appl Environ Microbiol. 2009. PMID: 19304832 Free PMC article.

2

Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.

Palaniappan N, Kim BS, Sekiyama Y, Osada H, Reynolds KA. Palaniappan N, et al. Among authors: reynolds ka. J Biol Chem. 2003 Sep 12;278(37):35552-7. doi: 10.1074/jbc.M305082200. Epub 2003 Jun 20. J Biol Chem. 2003. PMID: 12819191 Free article.

3

The plmS2-encoded cytochrome P450 monooxygenase mediates hydroxylation of phoslactomycin B in Streptomyces sp. strain HK803.

Ghatge MS, Reynolds KA. Ghatge MS, et al. Among authors: reynolds ka. J Bacteriol. 2005 Dec;187(23):7970-6. doi: 10.1128/JB.187.23.7970-7976.2005. J Bacteriol. 2005. PMID: 16291670 Free PMC article.

4

Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors.

Ghatge M, Palaniappan N, Das Choudhuri S, Reynolds K. Ghatge M, et al. J Ind Microbiol Biotechnol. 2006 Jul;33(7):589-99. doi: 10.1007/s10295-006-0116-1. Epub 2006 Apr 12. J Ind Microbiol Biotechnol. 2006. PMID: 16609856 Review.

5

Production of hygromycin A analogs in Streptomyces hygroscopicus NRRL 2388 through identification and manipulation of the biosynthetic gene cluster.

Palaniappan N, Ayers S, Gupta S, Habib el-S, Reynolds KA. Palaniappan N, et al. Among authors: reynolds ka. Chem Biol. 2006 Jul;13(7):753-64. doi: 10.1016/j.chembiol.2006.05.013. Chem Biol. 2006. PMID: 16873023

6

Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).

Alhamadsheh MM, Waters NC, Huddler DP, Kreishman-Deitrick M, Florova G, Reynolds KA. Alhamadsheh MM, et al. Among authors: reynolds ka. Bioorg Med Chem Lett. 2007 Feb 15;17(4):879-83. doi: 10.1016/j.bmcl.2006.11.067. Epub 2006 Dec 1. Bioorg Med Chem Lett. 2007. PMID: 17189694

7

Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis.

Alhamadsheh MM, Palaniappan N, Daschouduri S, Reynolds KA. Alhamadsheh MM, et al. Among authors: reynolds ka. J Am Chem Soc. 2007 Feb 21;129(7):1910-1. doi: 10.1021/ja068818t. Epub 2007 Jan 27. J Am Chem Soc. 2007. PMID: 17256943 Free PMC article.

8

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes.

Alhamadsheh MM, Musayev F, Komissarov AA, Sachdeva S, Wright HT, Scarsdale N, Florova G, Reynolds KA. Alhamadsheh MM, et al. Among authors: reynolds ka. Chem Biol. 2007 May;14(5):513-24. doi: 10.1016/j.chembiol.2007.03.013. Chem Biol. 2007. PMID: 17524982

9

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates.

Sachdeva S, Musayev F, Alhamadsheh MM, Neel Scarsdale J, Tonie Wright H, Reynolds KA. Sachdeva S, et al. Among authors: reynolds ka. Bioorg Chem. 2008 Apr;36(2):85-90. doi: 10.1016/j.bioorg.2007.11.001. Epub 2007 Dec 21. Bioorg Chem. 2008. PMID: 18096200 Free PMC article.

10

Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis.

Mo S, Sydor PK, Corre C, Alhamadsheh MM, Stanley AE, Haynes SW, Song L, Reynolds KA, Challis GL. Mo S, et al. Among authors: reynolds ka. Chem Biol. 2008 Feb;15(2):137-48. doi: 10.1016/j.chembiol.2007.11.015. Chem Biol. 2008. PMID: 18291318

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