Riordan JR - Search Results

1

Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.

Hegedus T, Aleksandrov A, Mengos A, Cui L, Jensen TJ, Riordan JR. Hegedus T, et al. Among authors: riordan jr. Biochim Biophys Acta. 2009 Jun;1788(6):1341-9. doi: 10.1016/j.bbamem.2009.03.015. Epub 2009 Mar 26. Biochim Biophys Acta. 2009. PMID: 19328185 Free article.

2

The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon.

Mall M, Kreda SM, Mengos A, Jensen TJ, Hirtz S, Seydewitz HH, Yankaskas J, Kunzelmann K, Riordan JR, Boucher RC. Mall M, et al. Among authors: riordan jr. Gastroenterology. 2004 Jan;126(1):32-41. doi: 10.1053/j.gastro.2003.10.049. Gastroenterology. 2004. PMID: 14699484

3

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive.

Hegedus T, Aleksandrov A, Cui L, Gentzsch M, Chang XB, Riordan JR. Hegedus T, et al. Among authors: riordan jr. Biochim Biophys Acta. 2006 May;1758(5):565-72. doi: 10.1016/j.bbamem.2006.03.006. Epub 2006 Mar 31. Biochim Biophys Acta. 2006. PMID: 16624253 Free article.

4

CFTR (ABCC7) is a hydrolyzable-ligand-gated channel.

Aleksandrov AA, Aleksandrov LA, Riordan JR. Aleksandrov AA, et al. Among authors: riordan jr. Pflugers Arch. 2007 Feb;453(5):693-702. doi: 10.1007/s00424-006-0140-z. Epub 2006 Sep 26. Pflugers Arch. 2007. PMID: 17021796 Review.

5

Domain interdependence in the biosynthetic assembly of CFTR.

Cui L, Aleksandrov L, Chang XB, Hou YX, He L, Hegedus T, Gentzsch M, Aleksandrov A, Balch WE, Riordan JR. Cui L, et al. Among authors: riordan jr. J Mol Biol. 2007 Jan 26;365(4):981-94. doi: 10.1016/j.jmb.2006.10.086. Epub 2006 Nov 10. J Mol Biol. 2007. PMID: 17113596

6

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function.

Serohijos AW, Hegedus T, Aleksandrov AA, He L, Cui L, Dokholyan NV, Riordan JR. Serohijos AW, et al. Among authors: riordan jr. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3256-61. doi: 10.1073/pnas.0800254105. Epub 2008 Feb 27. Proc Natl Acad Sci U S A. 2008. PMID: 18305154 Free PMC article.

7

Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR.

Hegedus T, Serohijos AW, Dokholyan NV, He L, Riordan JR. Hegedus T, et al. Among authors: riordan jr. J Mol Biol. 2008 May 16;378(5):1052-63. doi: 10.1016/j.jmb.2008.03.033. Epub 2008 Mar 26. J Mol Biol. 2008. PMID: 18423665 Free PMC article.

8

Diminished self-chaperoning activity of the DeltaF508 mutant of CFTR results in protein misfolding.

Serohijos AW, Hegedus T, Riordan JR, Dokholyan NV. Serohijos AW, et al. Among authors: riordan jr. PLoS Comput Biol. 2008 Feb 29;4(2):e1000008. doi: 10.1371/journal.pcbi.1000008. PLoS Comput Biol. 2008. PMID: 18463704 Free PMC article.

9

Mg2+ -dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2).

Aleksandrov L, Aleksandrov A, Riordan JR. Aleksandrov L, et al. Among authors: riordan jr. Biochem J. 2008 Nov 15;416(1):129-36. doi: 10.1042/BJ20081068. Biochem J. 2008. PMID: 18605986

10

Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating.

He L, Aleksandrov AA, Serohijos AW, Hegedus T, Aleksandrov LA, Cui L, Dokholyan NV, Riordan JR. He L, et al. Among authors: riordan jr. J Biol Chem. 2008 Sep 26;283(39):26383-90. doi: 10.1074/jbc.M803894200. Epub 2008 Jul 25. J Biol Chem. 2008. PMID: 18658148 Free PMC article.

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