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Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.
Parry JD, Pointon AV, Lutz U, Teichert F, Charlwood JK, Chan PH, Athersuch TJ, Taylor EL, Singh R, Luo J, Phillips KM, Vetillard A, Lyon JJ, Keun HC, Lutz WK, Gant TW. Parry JD, et al. Among authors: gant tw. Chem Res Toxicol. 2009 Apr;22(4):717-25. doi: 10.1021/tx800472z. Chem Res Toxicol. 2009. PMID: 19338340
In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.
Kamola PJ, Kitson JD, Turner G, Maratou K, Eriksson S, Panjwani A, Warnock LC, Douillard Guilloux GA, Moores K, Koppe EL, Wixted WE, Wilson PA, Gooderham NJ, Gant TW, Clark KL, Hughes SA, Edbrooke MR, Parry JD. Kamola PJ, et al. Among authors: gant tw. Nucleic Acids Res. 2015 Oct 15;43(18):8638-50. doi: 10.1093/nar/gkv857. Epub 2015 Sep 3. Nucleic Acids Res. 2015. PMID: 26338776 Free PMC article.
Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.
Kamola PJ, Maratou K, Wilson PA, Rush K, Mullaney T, McKevitt T, Evans P, Ridings J, Chowdhury P, Roulois A, Fairchild A, McCawley S, Cartwright K, Gooderham NJ, Gant TW, Moores K, Hughes SA, Edbrooke MR, Clark K, Parry JD. Kamola PJ, et al. Among authors: gant tw. Mol Ther Nucleic Acids. 2017 Sep 15;8:383-394. doi: 10.1016/j.omtn.2017.07.003. Epub 2017 Jul 8. Mol Ther Nucleic Acids. 2017. PMID: 28918038 Free PMC article.
122 results