Fricks IP - Search Results

1

Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems.

Fricks IP, Carter RL, Lazarowski ER, Harden TK. Fricks IP, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8. doi: 10.1124/jpet.109.150730. Epub 2009 Apr 1. J Pharmacol Exp Ther. 2009. PMID: 19339661 Free PMC article.

2

Signalling and pharmacological properties of the P2Y receptor.

Harden TK, Sesma JI, Fricks IP, Lazarowski ER. Harden TK, et al. Among authors: fricks ip. Acta Physiol (Oxf). 2010 Jun;199(2):149-60. doi: 10.1111/j.1748-1716.2010.02116.x. Epub 2010 Mar 24. Acta Physiol (Oxf). 2010. PMID: 20345417 Free PMC article. Review.

3

UDP is a competitive antagonist at the human P2Y14 receptor.

Fricks IP, Maddileti S, Carter RL, Lazarowski ER, Nicholas RA, Jacobson KA, Harden TK. Fricks IP, et al. J Pharmacol Exp Ther. 2008 May;325(2):588-94. doi: 10.1124/jpet.108.136309. Epub 2008 Feb 5. J Pharmacol Exp Ther. 2008. PMID: 18252808 Free PMC article.

4

Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.

Carter RL, Fricks IP, Barrett MO, Burianek LE, Zhou Y, Ko H, Das A, Jacobson KA, Lazarowski ER, Harden TK. Carter RL, et al. Among authors: fricks ip. Mol Pharmacol. 2009 Dec;76(6):1341-8. doi: 10.1124/mol.109.058578. Epub 2009 Sep 16. Mol Pharmacol. 2009. PMID: 19759354 Free PMC article.

5

Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor.

Ko H, Fricks I, Ivanov AA, Harden TK, Jacobson KA. Ko H, et al. J Med Chem. 2007 May 3;50(9):2030-9. doi: 10.1021/jm061222w. Epub 2007 Apr 4. J Med Chem. 2007. PMID: 17407275 Free PMC article.

6

Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose.

Ko H, Das A, Carter RL, Fricks IP, Zhou Y, Ivanov AA, Melman A, Joshi BV, Kovác P, Hajduch J, Kirk KL, Harden TK, Jacobson KA. Ko H, et al. Among authors: fricks ip. Bioorg Med Chem. 2009 Jul 15;17(14):5298-311. doi: 10.1016/j.bmc.2009.05.024. Epub 2009 May 15. Bioorg Med Chem. 2009. PMID: 19502066 Free PMC article.

7

Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.

Tosh DK, Yoo LS, Chinn M, Hong K, Kilbey SM 2nd, Barrett MO, Fricks IP, Harden TK, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: fricks ip. Bioconjug Chem. 2010 Feb 17;21(2):372-84. doi: 10.1021/bc900473v. Bioconjug Chem. 2010. PMID: 20121074 Free PMC article.

8

Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.

Ivanov AA, Ko H, Cosyn L, Maddileti S, Besada P, Fricks I, Costanzi S, Harden TK, Calenbergh SV, Jacobson KA. Ivanov AA, et al. J Med Chem. 2007 Mar 22;50(6):1166-76. doi: 10.1021/jm060903o. Epub 2007 Feb 16. J Med Chem. 2007. PMID: 17302398 Free PMC article.

9

17beta-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia.

Coakley RD, Sun H, Clunes LA, Rasmussen JE, Stackhouse JR, Okada SF, Fricks I, Young SL, Tarran R. Coakley RD, et al. J Clin Invest. 2008 Dec;118(12):4025-35. doi: 10.1172/JCI33893. Epub 2008 Nov 20. J Clin Invest. 2008. PMID: 19033671 Free PMC article.

10

Molecular dynamics simulation of the P2Y14 receptor. Ligand docking and identification of a putative binding site of the distal hexose moiety.

Ivanov AA, Fricks I, Kendall Harden T, Jacobson KA. Ivanov AA, et al. Bioorg Med Chem Lett. 2007 Feb 1;17(3):761-6. doi: 10.1016/j.bmcl.2006.10.081. Epub 2006 Oct 28. Bioorg Med Chem Lett. 2007. PMID: 17088057 Free PMC article.

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