Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulations.
Suenaga A, Kiyatkin AB, Hatakeyama M, Futatsugi N, Okimoto N, Hirano Y, Narumi T, Kawai A, Susukita R, Koishi T, Furusawa H, Yasuoka K, Takada N, Ohno Y, Taiji M, Ebisuzaki T, Hoek JB, Konagaya A, Kholodenko BN.
Suenaga A, et al. Among authors: narumi t.
J Biol Chem. 2004 Feb 6;279(6):4657-62. doi: 10.1074/jbc.M310598200. Epub 2003 Nov 12.
J Biol Chem. 2004.
PMID: 14613932
Free article.