Yoshimoto R - Search Results

1

5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool.

Shimamura K, Kitazawa H, Miyamoto Y, Kanesaka M, Nagumo A, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S. Shimamura K, et al. Among authors: yoshimoto r. J Pharmacol Exp Ther. 2009 Jul;330(1):249-56. doi: 10.1124/jpet.109.150854. Epub 2009 Apr 9. J Pharmacol Exp Ther. 2009. PMID: 19359527

2

Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Takahashi T, Nagase T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Takahashi T, et al. Among authors: yoshimoto r. J Med Chem. 2009 May 28;52(10):3142-5. doi: 10.1021/jm900391x. J Med Chem. 2009. PMID: 19388647

3

Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Nagase T, Takahashi T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Nagase T, et al. Among authors: yoshimoto r. J Med Chem. 2009 Jul 23;52(14):4111-4. doi: 10.1021/jm900488k. J Med Chem. 2009. PMID: 19522500

4

Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Sasaki T, Nagase T, Takahashi T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Sasaki T, et al. Among authors: yoshimoto r. Bioorg Med Chem. 2009 Aug 1;17(15):5639-47. doi: 10.1016/j.bmc.2009.06.042. Epub 2009 Jun 26. Bioorg Med Chem. 2009. PMID: 19596583

5

Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors.

Mizutani T, Ishikawa S, Nagase T, Takahashi H, Fujimura T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Mizutani T, et al. Among authors: yoshimoto r. J Med Chem. 2009 Nov 26;52(22):7289-300. doi: 10.1021/jm900915x. J Med Chem. 2009. PMID: 19883081

6

Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6.

Shimamura K, Nagumo A, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S. Shimamura K, et al. Among authors: yoshimoto r. Eur J Pharmacol. 2010 Mar 25;630(1-3):34-41. doi: 10.1016/j.ejphar.2009.12.033. Epub 2010 Jan 4. Eur J Pharmacol. 2010. PMID: 20045404

7

Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor.

Ito S, Yoshimoto R, Miyamoto Y, Mitobe Y, Nakamura T, Ishihara A, MacNeil DJ, Kanatani A, Tokita S. Ito S, et al. Among authors: yoshimoto r. Eur J Pharmacol. 2006 Jan 4;529(1-3):40-6. doi: 10.1016/j.ejphar.2005.10.066. Epub 2005 Nov 28. Eur J Pharmacol. 2006. PMID: 16316645

8

Impaired drinking response in histamine H3 receptor knockout mice following dehydration or angiotensin-II challenge.

Yoshimoto R, Miyamoto Y, Takahashi K, Kotani H, Kanatani A, Tokita S. Yoshimoto R, et al. Pharmacol Biochem Behav. 2006 Jul;84(3):504-10. doi: 10.1016/j.pbb.2006.06.014. Epub 2006 Aug 2. Pharmacol Biochem Behav. 2006. PMID: 16887177

9

Distinctive role of central histamine H3 receptor in various orexigenic pathways.

Yoshimoto R, Kanatani A, Tokita S. Yoshimoto R, et al. Eur J Pharmacol. 2008 Jan 28;579(1-3):229-32. doi: 10.1016/j.ejphar.2007.11.001. Epub 2007 Nov 13. Eur J Pharmacol. 2008. PMID: 18037404

10

Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists.

Nagase T, Mizutani T, Ishikawa S, Sekino E, Sasaki T, Fujimura T, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Fukami T, Sato N. Nagase T, et al. Among authors: yoshimoto r. J Med Chem. 2008 Aug 14;51(15):4780-9. doi: 10.1021/jm8003834. Epub 2008 Jul 4. J Med Chem. 2008. PMID: 18598020

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