Gopalsamy A - Search Results

1

Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors.

Gopalsamy A, Ciszewski G, Hu Y, Lee F, Feldberg L, Frommer E, Kim S, Collins K, Wojciechowicz D, Mallon R. Gopalsamy A, et al. Bioorg Med Chem Lett. 2009 May 15;19(10):2735-8. doi: 10.1016/j.bmcl.2009.03.129. Epub 2009 Mar 28. Bioorg Med Chem Lett. 2009. PMID: 19362830

2

Discovery of dibenzo[c,f][2,7]naphthyridines as potent and selective 3-phosphoinositide-dependent kinase-1 inhibitors.

Gopalsamy A, Shi M, Boschelli DH, Williamson R, Olland A, Hu Y, Krishnamurthy G, Han X, Arndt K, Guo B. Gopalsamy A, et al. J Med Chem. 2007 Nov 15;50(23):5547-9. doi: 10.1021/jm070851i. Epub 2007 Oct 17. J Med Chem. 2007. PMID: 17941624

3

Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.

Berger DM, Torres N, Dutia M, Powell D, Ciszewski G, Gopalsamy A, Levin JI, Kim KH, Xu W, Wilhelm J, Hu Y, Collins K, Feldberg L, Kim S, Frommer E, Wojciechowicz D, Mallon R. Berger DM, et al. Among authors: gopalsamy a. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23. doi: 10.1016/j.bmcl.2009.10.049. Epub 2009 Oct 26. Bioorg Med Chem Lett. 2009. PMID: 19864136

4

Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors.

Gopalsamy A, Ciszewski G, Shi M, Berger D, Hu Y, Lee F, Feldberg L, Frommer E, Kim S, Collins K, Wojciechowicz D, Mallon R. Gopalsamy A, et al. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. doi: 10.1016/j.bmcl.2009.10.074. Epub 2009 Oct 22. Bioorg Med Chem Lett. 2009. PMID: 19884006

5

B-Raf kinase inhibitors: hit enrichment through scaffold hopping.

Gopalsamy A, Shi M, Hu Y, Lee F, Feldberg L, Frommer E, Kim S, Collins K, Wojciechowicz D, Mallon R. Gopalsamy A, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2431-4. doi: 10.1016/j.bmcl.2010.03.030. Epub 2010 Mar 9. Bioorg Med Chem Lett. 2010. PMID: 20307980

6

Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

Gavrin LK, Green N, Hu Y, Janz K, Kaila N, Li HQ, Tam SY, Thomason JR, Gopalsamy A, Ciszewski G, Cuozzo JW, Hall JP, Hsu S, Telliez JB, Lin LL. Gavrin LK, et al. Among authors: gopalsamy a. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92. doi: 10.1016/j.bmcl.2005.08.029. Epub 2005 Sep 13. Bioorg Med Chem Lett. 2005. PMID: 16165349

7

Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.

Gopalsamy A, Shi M, Golas J, Vogan E, Jacob J, Johnson M, Lee F, Nilakantan R, Petersen R, Svenson K, Chopra R, Tam MS, Wen Y, Ellingboe J, Arndt K, Boschelli F. Gopalsamy A, et al. J Med Chem. 2008 Feb 14;51(3):373-5. doi: 10.1021/jm701385c. Epub 2008 Jan 16. J Med Chem. 2008. PMID: 18197612

8

Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

Gopalsamy A, Lim K, Ellingboe JW, Krishnamurthy G, Orlowski M, Feld B, van Zeijl M, Howe AY. Gopalsamy A, et al. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4221-4. doi: 10.1016/j.bmcl.2004.06.013. Bioorg Med Chem Lett. 2004. PMID: 15261274

9

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region.

Gopalsamy A, Yang H, Ellingboe JW, Tsou HR, Zhang N, Honores E, Powell D, Miranda M, McGinnis JP, Rabindran SK. Gopalsamy A, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1591-4. doi: 10.1016/j.bmcl.2005.01.066. Bioorg Med Chem Lett. 2005. PMID: 15745803

10

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: exploration of core and headpiece structure-activity relationships.

Powell D, Gopalsamy A, Wang YD, Zhang N, Miranda M, McGinnis JP, Rabindran SK. Powell D, et al. Among authors: gopalsamy a. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1641-5. doi: 10.1016/j.bmcl.2006.12.116. Epub 2007 Jan 13. Bioorg Med Chem Lett. 2007. PMID: 17275298

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