Middleton MR - Search Results

1

A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma.

Kefford RF, Thomas NP, Corrie PG, Palmer C, Abdi E, Kotasek D, Beith J, Ranson M, Mortimer P, Watson AJ, Margison GP, Middleton MR. Kefford RF, et al. Among authors: middleton mr. Br J Cancer. 2009 Apr 21;100(8):1245-9. doi: 10.1038/sj.bjc.6605016. Epub 2009 Mar 31. Br J Cancer. 2009. PMID: 19367282 Free PMC article. Clinical Trial.

2

O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.

Middleton MR, Lunn JM, Morris C, Rustin G, Wedge SR, Brampton MH, Lind MJ, Lee SM, Newell DR, Bleehen NM, Newlands ES, Calvert AH, Margison GP, Thatcher N. Middleton MR, et al. Br J Cancer. 1998 Nov;78(9):1199-202. doi: 10.1038/bjc.1998.654. Br J Cancer. 1998. PMID: 9820180 Free PMC article. Clinical Trial.

3

O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts.

Middleton MR, Kelly J, Thatcher N, Donnelly DJ, McElhinney RS, McMurry TB, McCormick JE, Margison GP. Middleton MR, et al. Int J Cancer. 2000 Jan 15;85(2):248-52. doi: 10.1002/(sici)1097-0215(20000115)85:2<248::aid-ijc16>3.0.co;2-v. Int J Cancer. 2000. PMID: 10629085

4

Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.

Middleton MR, Kelly J, Goodger S, Thatcher N, Margison GP. Middleton MR, et al. Cancer Chemother Pharmacol. 2000;45(1):15-20. doi: 10.1007/PL00006737. Cancer Chemother Pharmacol. 2000. PMID: 10647496

5

A randomized phase III study comparing dacarbazine, BCNU, cisplatin and tamoxifen with dacarbazine and interferon in advanced melanoma.

Middleton MR, Lorigan P, Owen J, Ashcroft L, Lee SM, Harper P, Thatcher N. Middleton MR, et al. Br J Cancer. 2000 Mar;82(6):1158-62. doi: 10.1054/bjoc.1999.1056. Br J Cancer. 2000. PMID: 10735499 Free PMC article. Clinical Trial.

6

O6-methylguanine formation, repair protein depletion and clinical outcome with a 4 hr schedule of temozolomide in the treatment of advanced melanoma: results of a phase II study.

Middleton MR, Lee SM, Arance A, Wood M, Thatcher N, Margison GP. Middleton MR, et al. Int J Cancer. 2000 Nov 1;88(3):469-73. Int J Cancer. 2000. PMID: 11054678 Clinical Trial.

7

Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model.

Middleton MR, Thatcher N, McMurry TB, McElhinney RS, Donnelly DJ, Margison GP. Middleton MR, et al. Int J Cancer. 2002 Aug 10;100(5):615-7. doi: 10.1002/ijc.10532. Int J Cancer. 2002. PMID: 12124813

8

Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway.

Middleton MR, Margison GP. Middleton MR, et al. Lancet Oncol. 2003 Jan;4(1):37-44. doi: 10.1016/s1470-2045(03)00959-8. Lancet Oncol. 2003. PMID: 12517538 Review.

9

Randomized phase II study of temozolomide given every 8 hours or daily with either interferon alfa-2b or thalidomide in metastatic malignant melanoma.

Danson S, Lorigan P, Arance A, Clamp A, Ranson M, Hodgetts J, Lomax L, Ashcroft L, Thatcher N, Middleton MR. Danson S, et al. Among authors: middleton mr. J Clin Oncol. 2003 Jul 1;21(13):2551-7. doi: 10.1200/JCO.2003.10.039. J Clin Oncol. 2003. PMID: 12829675 Clinical Trial.

10

Phase III trial of gemcitabine and carboplatin versus mitomycin, ifosfamide, and cisplatin or mitomycin, vinblastine, and cisplatin in patients with advanced nonsmall cell lung carcinoma.

Danson S, Middleton MR, O'Byrne KJ, Clemons M, Ranson M, Hassan J, Anderson H, Burt PA, Fairve-Finn C, Stout R, Dowd I, Ashcroft L, Beresford C, Thatcher N. Danson S, et al. Among authors: middleton mr. Cancer. 2003 Aug 1;98(3):542-53. doi: 10.1002/cncr.11535. Cancer. 2003. PMID: 12879472 Free article. Clinical Trial.

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