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Page 1
Discovery of 4-azaindoles as novel inhibitors of c-Met kinase.
Porter J, Lumb S, Franklin RJ, Gascon-Simorte JM, Calmiano M, Riche KL, Lallemand B, Keyaerts J, Edwards H, Maloney A, Delgado J, King L, Foley A, Lecomte F, Reuberson J, Meier C, Batchelor M. Porter J, et al. Among authors: lumb s. Bioorg Med Chem Lett. 2009 May 15;19(10):2780-4. doi: 10.1016/j.bmcl.2009.03.110. Epub 2009 Mar 27. Bioorg Med Chem Lett. 2009. PMID: 19369077
Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.
Porter J, Lumb S, Lecomte F, Reuberson J, Foley A, Calmiano M, le Riche K, Edwards H, Delgado J, Franklin RJ, Gascon-Simorte JM, Maloney A, Meier C, Batchelor M. Porter J, et al. Among authors: lumb s. Bioorg Med Chem Lett. 2009 Jan 15;19(2):397-400. doi: 10.1016/j.bmcl.2008.11.062. Epub 2008 Nov 21. Bioorg Med Chem Lett. 2009. PMID: 19059779
Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Adams R, Burnley RJ, Valenzano CR, Qureshi O, Doyle C, Lumb S, Del Carmen Lopez M, Griffin R, McMillan D, Taylor RD, Meier C, Mori P, Griffin LM, Wernery U, Kinne J, Rapecki S, Baker TS, Lawson AD, Wright M, Ettorre A. Adams R, et al. Among authors: lumb s. Sci Rep. 2017 Jan 30;7:37716. doi: 10.1038/srep37716. Sci Rep. 2017. PMID: 28134246 Free PMC article.
The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.
Hughes B, Howat D, Lisle H, Holbrook M, James T, Gozzard N, Blease K, Hughes P, Kingaby R, Warrellow G, Alexander R, Head J, Boyd E, Eaton M, Perry M, Wales M, Smith B, Owens R, Catterall C, Lumb S, Russell A, Allen R, Merriman M, Bloxham D, Higgs G. Hughes B, et al. Among authors: lumb s. Br J Pharmacol. 1996 Jul;118(5):1183-91. doi: 10.1111/j.1476-5381.1996.tb15522.x. Br J Pharmacol. 1996. PMID: 8818342 Free PMC article.
CDP840: a novel inhibitor of PDE-4.
Perry MJ, O'Connell J, Walker C, Crabbe T, Baldock D, Russell A, Lumb S, Huang Z, Howat D, Allen R, Merriman M, Walls J, Daniel T, Hughes B, Laliberte F, Higgs GA, Owens RJ. Perry MJ, et al. Among authors: lumb s. Cell Biochem Biophys. 1998;29(1-2):113-32. doi: 10.1007/BF02737831. Cell Biochem Biophys. 1998. PMID: 9631241
Molecular cloning and expression of a human phosphodiesterase 4C.
Owens RJ, Lumb S, Rees-Milton K, Russell A, Baldock D, Lang V, Crabbe T, Ballesteros M, Perry MJ. Owens RJ, et al. Among authors: lumb s. Cell Signal. 1997 Dec;9(8):575-85. doi: 10.1016/s0898-6568(97)00072-7. Cell Signal. 1997. PMID: 9429761
Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma.
Singhania A, Rupani H, Jayasekera N, Lumb S, Hales P, Gozzard N, Davies DE, Woelk CH, Howarth PH. Singhania A, et al. Among authors: lumb s. PLoS One. 2017 Jan 3;12(1):e0168680. doi: 10.1371/journal.pone.0168680. eCollection 2017. PLoS One. 2017. PMID: 28045928 Free PMC article.
13 results