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Assessing proarrhythmic potential of drugs when optimal studies are infeasible.
Rock EP, Finkle J, Fingert HJ, Booth BP, Garnett CE, Grant S, Justice RL, Kovacs RJ, Kowey PR, Rodriguez I, Sanhai WR, Strnadova C, Targum SL, Tsong Y, Uhl K, Stockbridge N. Rock EP, et al. Among authors: garnett ce. Am Heart J. 2009 May;157(5):827-36, 836.e1. doi: 10.1016/j.ahj.2009.02.020. Am Heart J. 2009. PMID: 19376308 Review.
Electrocardiographic assessment for therapeutic proteins--scientific discussion.
Rodriguez I, Erdman A, Padhi D, Garnett CE, Zhao H, Targum SL, Balakrishnan S, Strnadova C, Viner N, Geiger MJ, Newton-Cheh C, Litwin J, Pugsley MK, Sager PT, Krucoff MW, Finkle JK. Rodriguez I, et al. Among authors: garnett ce. Am Heart J. 2010 Oct;160(4):627-34. doi: 10.1016/j.ahj.2010.07.001. Am Heart J. 2010. PMID: 20934555 Review.
Practice and challenges of thorough QT studies.
Stockbridge N, Zhang J, Garnett C, Malik M. Stockbridge N, et al. J Electrocardiol. 2012 Nov-Dec;45(6):582-7. doi: 10.1016/j.jelectrocard.2012.07.020. Epub 2012 Sep 19. J Electrocardiol. 2012. PMID: 22999322 Review.
The IQ-CSRC prospective clinical Phase 1 study: "Can early QT assessment using exposure response analysis replace the thorough QT study?".
Darpo B, Sarapa N, Garnett C, Benson C, Dota C, Ferber G, Jarugula V, Johannesen L, Keirns J, Krudys K, Ortemann-Renon C, Riley S, Rogers-Subramaniam D, Stockbridge N. Darpo B, et al. Ann Noninvasive Electrocardiol. 2014 Jan;19(1):70-81. doi: 10.1111/anec.12128. Epub 2013 Dec 30. Ann Noninvasive Electrocardiol. 2014. PMID: 24372708 Free PMC article. Review.
Cardiac Safety Research Consortium: can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies? Scientific update and a research proposal for a path forward.
Darpo B, Garnett C, Benson CT, Keirns J, Leishman D, Malik M, Mehrotra N, Prasad K, Riley S, Rodriguez I, Sager P, Sarapa N, Wallis R. Darpo B, et al. Am Heart J. 2014 Sep;168(3):262-72. doi: 10.1016/j.ahj.2014.06.003. Epub 2014 Jun 6. Am Heart J. 2014. PMID: 25173536
68 results