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ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A. Ohno Y, et al. Among authors: kihara a. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18439-44. doi: 10.1073/pnas.1005572107. Epub 2010 Oct 11. Proc Natl Acad Sci U S A. 2010. PMID: 20937905 Free PMC article.
Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile.
Abe K, Ohno Y, Sassa T, Taguchi R, Çalışkan M, Ober C, Kihara A. Abe K, et al. Among authors: kihara a. J Biol Chem. 2013 Dec 20;288(51):36741-9. doi: 10.1074/jbc.M113.493221. Epub 2013 Nov 12. J Biol Chem. 2013. PMID: 24220030 Free PMC article.
375 results