Wang L - Search Results

1

Polymerase-tailored variations in the water-mediated and substrate-assisted mechanism for nucleotidyl transfer: insights from a study of T7 DNA polymerase.

Wang L, Broyde S, Zhang Y. Wang L, et al. J Mol Biol. 2009 Jun 19;389(4):787-96. doi: 10.1016/j.jmb.2009.04.029. Epub 2009 Apr 21. J Mol Biol. 2009. PMID: 19389406 Free PMC article.

2

A water-mediated and substrate-assisted catalytic mechanism for Sulfolobus solfataricus DNA polymerase IV.

Wang L, Yu X, Hu P, Broyde S, Zhang Y. Wang L, et al. J Am Chem Soc. 2007 Apr 18;129(15):4731-7. doi: 10.1021/ja068821c. Epub 2007 Mar 22. J Am Chem Soc. 2007. PMID: 17375926 Free PMC article.

3

DNA adduct structure-function relationships: comparing solution with polymerase structures.

Broyde S, Wang L, Zhang L, Rechkoblit O, Geacintov NE, Patel DJ. Broyde S, et al. Among authors: wang l. Chem Res Toxicol. 2008 Jan;21(1):45-52. doi: 10.1021/tx700193x. Epub 2007 Dec 4. Chem Res Toxicol. 2008. PMID: 18052109 Free PMC article. Review.

4

Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion.

Lior-Hoffmann L, Wang L, Wang S, Geacintov NE, Broyde S, Zhang Y. Lior-Hoffmann L, et al. Among authors: wang l, wang s. Nucleic Acids Res. 2012 Oct;40(18):9193-205. doi: 10.1093/nar/gks653. Epub 2012 Jul 5. Nucleic Acids Res. 2012. PMID: 22772988 Free PMC article.

5

Accurate representation of B-DNA double helical structure with implicit solvent and counterions.

Wang L, Hingerty BE, Srinivasan AR, Olson WK, Broyde S. Wang L, et al. Biophys J. 2002 Jul;83(1):382-406. doi: 10.1016/S0006-3495(02)75177-1. Biophys J. 2002. PMID: 12080128 Free PMC article.

6

Structural and stereoisomer effects of model estrogen quinone-derived DNA adducts: N6-(2-hydroxyestron-6(alpha,beta)-yl)-2'-deoxyadenosine and N2-(2-hydroxyestron-6(alpha,beta)-yl)-2'-deoxyguanosine.

Wang L, Hingerty BE, Shapiro R, Broyde S. Wang L, et al. Chem Res Toxicol. 2004 Mar;17(3):311-24. doi: 10.1021/tx034218l. Chem Res Toxicol. 2004. PMID: 15025501

7

Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations.

Wang L, Wu M, Yan SF, Patel DJ, Geacintov NE, Broyde S. Wang L, et al. Chem Res Toxicol. 2005 Mar;18(3):441-56. doi: 10.1021/tx049786v. Chem Res Toxicol. 2005. PMID: 15777084 Free PMC article.

8

A new anti conformation for N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson-Crick pairing in the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4).

Wang L, Broyde S. Wang L, et al. Nucleic Acids Res. 2006 Feb 1;34(3):785-95. doi: 10.1093/nar/gkj479. Print 2006. Nucleic Acids Res. 2006. PMID: 16452300 Free PMC article.

9

Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies.

Zhang L, Rechkoblit O, Wang L, Patel DJ, Shapiro R, Broyde S. Zhang L, et al. Among authors: wang l. Nucleic Acids Res. 2006 Jul 4;34(11):3326-37. doi: 10.1093/nar/gkl425. Print 2006. Nucleic Acids Res. 2006. PMID: 16820532 Free PMC article.

10

Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase.

Perlow-Poehnelt RA, Likhterov I, Wang L, Scicchitano DA, Geacintov NE, Broyde S. Perlow-Poehnelt RA, et al. Among authors: wang l. J Biol Chem. 2007 Jan 12;282(2):1397-408. doi: 10.1074/jbc.M606769200. Epub 2006 Nov 6. J Biol Chem. 2007. PMID: 17090533 Free article.

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