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Abaloparatide, a novel osteoanabolic PTHrP analog, increases cortical and trabecular bone mass and architecture in orchiectomized rats by increasing bone formation without increasing bone resorption.
Chandler H, Lanske B, Varela A, Guillot M, Boyer M, Brown J, Pierce A, Ominsky M, Mitlak B, Baron R, Kostenuik P, Hattersley G. Chandler H, et al. Among authors: ominsky m. Bone. 2019 Mar;120:148-155. doi: 10.1016/j.bone.2018.10.012. Epub 2018 Oct 19. Bone. 2019. PMID: 30343166
Abaloparatide, a novel PTH receptor agonist, increased bone mass and strength in ovariectomized cynomolgus monkeys by increasing bone formation without increasing bone resorption.
Doyle N, Varela A, Haile S, Guldberg R, Kostenuik PJ, Ominsky MS, Smith SY, Hattersley G. Doyle N, et al. Among authors: ominsky ms. Osteoporos Int. 2018 Mar;29(3):685-697. doi: 10.1007/s00198-017-4323-6. Epub 2017 Dec 19. Osteoporos Int. 2018. PMID: 29260289 Free PMC article.
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL.
Kostenuik PJ, Nguyen HQ, McCabe J, Warmington KS, Kurahara C, Sun N, Chen C, Li L, Cattley RC, Van G, Scully S, Elliott R, Grisanti M, Morony S, Tan HL, Asuncion F, Li X, Ominsky MS, Stolina M, Dwyer D, Dougall WC, Hawkins N, Boyle WJ, Simonet WS, Sullivan JK. Kostenuik PJ, et al. Among authors: ominsky ms. J Bone Miner Res. 2009 Feb;24(2):182-95. doi: 10.1359/jbmr.081112. J Bone Miner Res. 2009. PMID: 19016581 Free article.
Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL.
Pierroz DD, Bonnet N, Baldock PA, Ominsky MS, Stolina M, Kostenuik PJ, Ferrari SL. Pierroz DD, et al. Among authors: ominsky ms. J Biol Chem. 2010 Sep 3;285(36):28164-73. doi: 10.1074/jbc.M110.101964. Epub 2010 Jun 17. J Biol Chem. 2010. PMID: 20558734 Free PMC article.
87 results