Booth RG - Search Results

1

(1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity.

Booth RG, Fang L, Huang Y, Wilczynski A, Sivendran S. Booth RG, et al. Eur J Pharmacol. 2009 Aug 1;615(1-3):1-9. doi: 10.1016/j.ejphar.2009.04.035. Epub 2009 May 3. Eur J Pharmacol. 2009. PMID: 19397907 Free PMC article.

2

Drug discovery targeting human 5-HT(2C) receptors: residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formation.

Canal CE, Cordova-Sintjago TC, Villa NY, Fang LJ, Booth RG. Canal CE, et al. Among authors: booth rg. Eur J Pharmacol. 2011 Dec 30;673(1-3):1-12. doi: 10.1016/j.ejphar.2011.10.006. Epub 2011 Oct 12. Eur J Pharmacol. 2011. PMID: 22020288 Free PMC article.

3

Molecular determinants of ligand-directed signaling for the histamine H1 receptor.

Booth RG, Fang L, Wilczynski A, Sivendren S, Sun Z, Travers S, Bruysters M, Sansuk K, Leurs R. Booth RG, et al. Inflamm Res. 2008;57 Suppl 1(0 1):S43-4. doi: 10.1007/s00011-007-0621-3. Inflamm Res. 2008. PMID: 18345497 Free PMC article. No abstract available.

4

Aromatic interactions impact ligand binding and function at serotonin 5-HT_2C G protein-coupled receptors: Receptor homology modeling, ligand docking, and molecular dynamics results validated by experimental studies.

Córdova-Sintjago T, Villa N, Fang L, Booth RG. Córdova-Sintjago T, et al. Among authors: booth rg. Mol Phys. 2014 Jan 1;112(3-4):398-407. doi: 10.1080/00268976.2013.833656. Mol Phys. 2014. PMID: 24729635 Free PMC article.

5

Ligand-directed serotonin 5-HT_2C receptor desensitization and sensitization.

Felsing DE, Canal CE, Booth RG. Felsing DE, et al. Among authors: booth rg. Eur J Pharmacol. 2019 Apr 5;848:131-139. doi: 10.1016/j.ejphar.2019.01.037. Epub 2019 Jan 25. Eur J Pharmacol. 2019. PMID: 30689993 Free PMC article.

6

Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors.

Sakhuja R, Kondabolu K, Córdova-Sintjago T, Travers S, Vincek AS, Kim MS, Abboud KA, Fang L, Sun Z, Canal CE, Booth RG. Sakhuja R, et al. Among authors: booth rg. Bioorg Med Chem. 2015 Apr 1;23(7):1588-600. doi: 10.1016/j.bmc.2015.01.060. Epub 2015 Feb 7. Bioorg Med Chem. 2015. PMID: 25703249 Free PMC article.

7

Effect of (-)-trans-PAT, a novel 5-HT2C receptor agonist, on intake of palatable food in mice.

Rowland NE, Crump EM, Nguyen N, Robertson K, Sun Z, Booth RG. Rowland NE, et al. Among authors: booth rg. Pharmacol Biochem Behav. 2008 Nov;91(1):176-80. doi: 10.1016/j.pbb.2008.07.004. Epub 2008 Jul 19. Pharmacol Biochem Behav. 2008. PMID: 18692085 Free PMC article.

8

The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats.

Kasper J, Tikamdas R, Kim MS, Macfadyen K, Aramini R, Ladd J, Bisceglia S, Booth R, Peris J. Kasper J, et al. Eur J Pharmacol. 2013 Oct 15;718(1-3):98-104. doi: 10.1016/j.ejphar.2013.09.008. Epub 2013 Sep 13. Eur J Pharmacol. 2013. PMID: 24041931 Free PMC article.

9

Molecular determinants of ligand binding at the human histamine H₁ receptor: Site-directed mutagenesis results analyzed with ligand docking and molecular dynamics studies at H₁ homology and crystal structure models.

Cordova-Sintjago TC, Fang L, Bruysters M, Leurs R, Booth RG. Cordova-Sintjago TC, et al. Among authors: booth rg. J Chem Pharm Res. 2012 Jun;4(6):2937-2951. J Chem Pharm Res. 2012. PMID: 25013351 Free PMC article.

10

A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses.

Canal CE, Morgan D, Felsing D, Kondabolu K, Rowland NE, Robertson KL, Sakhuja R, Booth RG. Canal CE, et al. Among authors: booth rg. J Pharmacol Exp Ther. 2014 May;349(2):310-8. doi: 10.1124/jpet.113.212373. Epub 2014 Feb 21. J Pharmacol Exp Ther. 2014. PMID: 24563531 Free PMC article.

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