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A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation.
Pavlowsky A, Gianfelice A, Pallotto M, Zanchi A, Vara H, Khelfaoui M, Valnegri P, Rezai X, Bassani S, Brambilla D, Kumpost J, Blahos J, Roux MJ, Humeau Y, Chelly J, Passafaro M, Giustetto M, Billuart P, Sala C. Pavlowsky A, et al. Curr Biol. 2010 Jan 26;20(2):103-15. doi: 10.1016/j.cub.2009.12.030. Epub 2010 Jan 21. Curr Biol. 2010. PMID: 20096586 Free article.
IL1RAPL1 controls inhibitory networks during cerebellar development in mice.
Gambino F, Kneib M, Pavlowsky A, Skala H, Heitz S, Vitale N, Poulain B, Khelfaoui M, Chelly J, Billuart P, Humeau Y. Gambino F, et al. Among authors: pavlowsky a. Eur J Neurosci. 2009 Oct;30(8):1476-86. doi: 10.1111/j.1460-9568.2009.06975.x. Epub 2009 Oct 7. Eur J Neurosci. 2009. PMID: 19811529
IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation.
Gambino F, Pavlowsky A, Béglé A, Dupont JL, Bahi N, Courjaret R, Gardette R, Hadjkacem H, Skala H, Poulain B, Chelly J, Vitale N, Humeau Y. Gambino F, et al. Among authors: pavlowsky a. Proc Natl Acad Sci U S A. 2007 May 22;104(21):9063-8. doi: 10.1073/pnas.0701133104. Epub 2007 May 14. Proc Natl Acad Sci U S A. 2007. PMID: 17502602 Free PMC article.
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