Meiler J - Search Results

1

The evolutionarily conserved residue A653 plays a key role in HERG channel closing.

Stepanovic SZ, Potet F, Petersen CI, Smith JA, Meiler J, Balser JR, Kupershmidt S. Stepanovic SZ, et al. Among authors: meiler j. J Physiol. 2009 Jun 1;587(Pt 11):2555-66. doi: 10.1113/jphysiol.2008.166694. Epub 2009 Apr 30. J Physiol. 2009. PMID: 19406877 Free PMC article.

2

Structural models for the KCNQ1 voltage-gated potassium channel.

Smith JA, Vanoye CG, George AL Jr, Meiler J, Sanders CR. Smith JA, et al. Among authors: meiler j. Biochemistry. 2007 Dec 11;46(49):14141-52. doi: 10.1021/bi701597s. Epub 2007 Nov 14. Biochemistry. 2007. PMID: 17999538 Free PMC article.

3

BCL::Align-sequence alignment and fold recognition with a custom scoring function online.

Dong E, Smith J, Heinze S, Alexander N, Meiler J. Dong E, et al. Among authors: meiler j. Gene. 2008 Oct 1;422(1-2):41-6. doi: 10.1016/j.gene.2008.06.006. Epub 2008 Jun 7. Gene. 2008. PMID: 18601985 Free PMC article.

4

Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel.

Kang C, Tian C, Sönnichsen FD, Smith JA, Meiler J, George AL Jr, Vanoye CG, Kim HJ, Sanders CR. Kang C, et al. Among authors: meiler j. Biochemistry. 2008 Aug 5;47(31):7999-8006. doi: 10.1021/bi800875q. Epub 2008 Jul 9. Biochemistry. 2008. PMID: 18611041 Free PMC article.

5

The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating.

Fallen K, Banerjee S, Sheehan J, Addison D, Lewis LM, Meiler J, Denton JS. Fallen K, et al. Among authors: meiler j. Channels (Austin). 2009 Jan-Feb;3(1):57-68. doi: 10.4161/chan.3.1.7817. Epub 2009 Jan 6. Channels (Austin). 2009. PMID: 19221509 Free PMC article.

6

An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.

Yang T, Smith JA, Leake BF, Sanders CR, Meiler J, Roden DM. Yang T, et al. Among authors: meiler j. Mol Pharmacol. 2013 Feb;83(2):481-9. doi: 10.1124/mol.112.081513. Epub 2012 Nov 28. Mol Pharmacol. 2013. PMID: 23193163 Free PMC article.

7

Structural basis for KCNE3 modulation of potassium recycling in epithelia.

Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL Jr, Meiler J, Vanoye CG, Sanders CR. Kroncke BM, et al. Among authors: meiler j. Sci Adv. 2016 Sep 9;2(9):e1501228. doi: 10.1126/sciadv.1501228. eCollection 2016 Sep. Sci Adv. 2016. PMID: 27626070 Free PMC article.

8

Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations.

Huang H, Kuenze G, Smith JA, Taylor KC, Duran AM, Hadziselimovic A, Meiler J, Vanoye CG, George AL Jr, Sanders CR. Huang H, et al. Among authors: meiler j. Sci Adv. 2018 Mar 7;4(3):eaar2631. doi: 10.1126/sciadv.aar2631. eCollection 2018 Mar. Sci Adv. 2018. PMID: 29532034 Free PMC article.

9

High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance.

Vanoye CG, Desai RR, Fabre KL, Gallagher SL, Potet F, DeKeyser JM, Macaya D, Meiler J, Sanders CR, George AL Jr. Vanoye CG, et al. Among authors: meiler j. Circ Genom Precis Med. 2018 Nov;11(11):e002345. doi: 10.1161/CIRCGEN.118.002345. Circ Genom Precis Med. 2018. PMID: 30571187 Free PMC article.

10

On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation.

Brown BP, Zhang YK, Westover D, Yan Y, Qiao H, Huang V, Du Z, Smith JA, Ross JS, Miller VA, Ali S, Bazhenova L, Schrock AB, Meiler J, Lovly CM. Brown BP, et al. Among authors: meiler j. Clin Cancer Res. 2019 Jun 1;25(11):3341-3351. doi: 10.1158/1078-0432.CCR-18-3829. Epub 2019 Feb 22. Clin Cancer Res. 2019. PMID: 30796031 Free PMC article.

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