Hart PJ - Search Results

1

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS.

Karch CM, Prudencio M, Winkler DD, Hart PJ, Borchelt DR. Karch CM, et al. Among authors: hart pj. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7774-9. doi: 10.1073/pnas.0902505106. Epub 2009 Apr 30. Proc Natl Acad Sci U S A. 2009. PMID: 19416874 Free PMC article.

2

Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease.

Prudencio M, Hart PJ, Borchelt DR, Andersen PM. Prudencio M, et al. Among authors: hart pj. Hum Mol Genet. 2009 Sep 1;18(17):3217-26. doi: 10.1093/hmg/ddp260. Epub 2009 May 30. Hum Mol Genet. 2009. PMID: 19483195 Free PMC article.

3

Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS.

Ivanova MI, Sievers SA, Guenther EL, Johnson LM, Winkler DD, Galaleldeen A, Sawaya MR, Hart PJ, Eisenberg DS. Ivanova MI, et al. Among authors: hart pj. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):197-201. doi: 10.1073/pnas.1320786110. Epub 2013 Dec 16. Proc Natl Acad Sci U S A. 2014. PMID: 24344300 Free PMC article.

4

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases.

Ayers JI, Xu G, Pletnikova O, Troncoso JC, Hart PJ, Borchelt DR. Ayers JI, et al. Among authors: hart pj. Acta Neuropathol Commun. 2014 May 14;2:55. doi: 10.1186/2051-5960-2-55. Acta Neuropathol Commun. 2014. PMID: 24887207 Free PMC article.

5

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.

Ayers JI, Diamond J, Sari A, Fromholt S, Galaleldeen A, Ostrow LW, Glass JD, Hart PJ, Borchelt DR. Ayers JI, et al. Among authors: hart pj. Acta Neuropathol. 2016 Dec;132(6):827-840. doi: 10.1007/s00401-016-1623-4. Epub 2016 Oct 4. Acta Neuropathol. 2016. PMID: 27704280 Free PMC article.

6

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis.

Crown AM, Roberts BL, Crosby K, Brown H, Ayers JI, Hart PJ, Borchelt DR. Crown AM, et al. Among authors: hart pj. G3 (Bethesda). 2019 Mar 7;9(3):719-728. doi: 10.1534/g3.118.200787. G3 (Bethesda). 2019. PMID: 30622123 Free PMC article.

7

Structural and biophysical properties of the pathogenic SOD1 variant H46R/H48Q.

Winkler DD, Schuermann JP, Cao X, Holloway SP, Borchelt DR, Carroll MC, Proescher JB, Culotta VC, Hart PJ. Winkler DD, et al. Among authors: hart pj. Biochemistry. 2009 Apr 21;48(15):3436-47. doi: 10.1021/bi8021735. Biochemistry. 2009. PMID: 19227972 Free PMC article.

8

Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis.

Seetharaman SV, Prudencio M, Karch C, Holloway SP, Borchelt DR, Hart PJ. Seetharaman SV, et al. Among authors: hart pj. Exp Biol Med (Maywood). 2009 Oct;234(10):1140-54. doi: 10.3181/0903-MR-104. Epub 2009 Jul 13. Exp Biol Med (Maywood). 2009. PMID: 19596823 Free PMC article. Review.

9

[No title available]

[No authors listed] [No authors listed] PMID: 33575758

10

Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability.

Wang J, Caruano-Yzermans A, Rodriguez A, Scheurmann JP, Slunt HH, Cao X, Gitlin J, Hart PJ, Borchelt DR. Wang J, et al. Among authors: hart pj. J Biol Chem. 2007 Jan 5;282(1):345-52. doi: 10.1074/jbc.M604503200. Epub 2006 Nov 8. J Biol Chem. 2007. PMID: 17092942 Free PMC article.

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