Höltje HD - Search Results

1

Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling.

Hillmann P, Ko GY, Spinrath A, Raulf A, von Kügelgen I, Wolff SC, Nicholas RA, Kostenis E, Höltje HD, Müller CE. Hillmann P, et al. Among authors: holtje hd. J Med Chem. 2009 May 14;52(9):2762-75. doi: 10.1021/jm801442p. J Med Chem. 2009. PMID: 19419204

2

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity.

Antony J, Kellershohn K, Mohr-Andrä M, Kebig A, Prilla S, Muth M, Heller E, Disingrini T, Dallanoce C, Bertoni S, Schrobang J, Tränkle C, Kostenis E, Christopoulos A, Höltje HD, Barocelli E, De Amici M, Holzgrabe U, Mohr K. Antony J, et al. Among authors: holtje hd. FASEB J. 2009 Feb;23(2):442-50. doi: 10.1096/fj.08-114751. Epub 2008 Oct 8. FASEB J. 2009. PMID: 18842964

3

Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation.

Jäger D, Schmalenbach C, Prilla S, Schrobang J, Kebig A, Sennwitz M, Heller E, Tränkle C, Holzgrabe U, Höltje HD, Mohr K. Jäger D, et al. Among authors: holtje hd. J Biol Chem. 2007 Nov 30;282(48):34968-76. doi: 10.1074/jbc.M705563200. Epub 2007 Sep 21. J Biol Chem. 2007. PMID: 17890226 Free article.

4

Kappa-opioid receptor model in a phospholipid bilayer: molecular dynamics simulation.

Iadanza M, Höltje M, Ronsisvalle G, Höltje HD. Iadanza M, et al. Among authors: holtje hd, holtje m. J Med Chem. 2002 Oct 24;45(22):4838-46. doi: 10.1021/jm0209127. J Med Chem. 2002. PMID: 12383009

5

N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.

Hackling A, Ghosh R, Perachon S, Mann A, Höltje HD, Wermuth CG, Schwartz JC, Sippl W, Sokoloff P, Stark H. Hackling A, et al. Among authors: holtje hd. J Med Chem. 2003 Aug 28;46(18):3883-99. doi: 10.1021/jm030836n. J Med Chem. 2003. PMID: 12930150

6

Molecular modelling studies on the ORL1-receptor and ORL1-agonists.

Bröer BM, Gurrath M, Höltje HD. Bröer BM, et al. Among authors: holtje hd. J Comput Aided Mol Des. 2003 Nov;17(11):739-54. doi: 10.1023/b:jcam.0000017491.97244.69. J Comput Aided Mol Des. 2003. PMID: 15072434

7

Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors.

Voigtländer U, Jöhren K, Mohr M, Raasch A, Tränkle C, Buller S, Ellis J, Höltje HD, Mohr K. Voigtländer U, et al. Among authors: holtje hd. Mol Pharmacol. 2003 Jul;64(1):21-31. doi: 10.1124/mol.64.1.21. Mol Pharmacol. 2003. PMID: 12815157

8

Targeting human DNA polymerase alpha for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding.

Richartz A, Höltje M, Brandt B, Schäfer-Korting M, Höltje HD. Richartz A, et al. Among authors: holtje hd, holtje m. J Enzyme Inhib Med Chem. 2008 Feb;23(1):94-100. doi: 10.1080/14756360701433414. J Enzyme Inhib Med Chem. 2008. PMID: 18341260 Free article.

9

Molecular modelling studies of new potential human DNA polymerase α inhibitors.

Zdrazil B, Schwanke A, Schmitz B, Schäfer-Korting M, Höltje HD. Zdrazil B, et al. Among authors: holtje hd. J Enzyme Inhib Med Chem. 2011 Apr;26(2):270-9. doi: 10.3109/14756366.2010.503609. Epub 2010 Oct 20. J Enzyme Inhib Med Chem. 2011. PMID: 20958230 Free article.

10

Human polymerase alpha inhibitors for skin tumors. Part 2. Modeling, synthesis and influence on normal and transformed keratinocytes of new thymidine and purine derivatives.

Höltje M, Richartz A, Zdrazil B, Schwanke A, Dugovic B, Murruzzu C, Reissig HU, Korting HC, Kleuser B, Höltje HD, Schäfer-Korting M. Höltje M, et al. Among authors: holtje hd. J Enzyme Inhib Med Chem. 2010 Apr;25(2):250-65. doi: 10.3109/14756360903059579. J Enzyme Inhib Med Chem. 2010. PMID: 20222764 Free article.

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