Terstappen GC - Search Results

1

How to achieve confidence in drug discovery and development: managing risk (from a reductionist to a holistic approach).

Bakker A, Caricasole A, Gaviraghi G, Pollio G, Robertson G, Terstappen GC, Salerno M, Tunici P. Bakker A, et al. Among authors: terstappen gc. ChemMedChem. 2009 Jun;4(6):923-33. doi: 10.1002/cmdc.200900056. ChemMedChem. 2009. PMID: 19434656

2

The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.

Terstappen GC, Gaviraghi G, Caricasole A. Terstappen GC, et al. IDrugs. 2006 Jan;9(1):35-8. IDrugs. 2006. PMID: 16374731

3

Target deconvolution strategies in drug discovery.

Terstappen GC, Schlüpen C, Raggiaschi R, Gaviraghi G. Terstappen GC, et al. Nat Rev Drug Discov. 2007 Nov;6(11):891-903. doi: 10.1038/nrd2410. Nat Rev Drug Discov. 2007. PMID: 17917669 Review.

4

Drug discovery and development for Huntington's disease - an orphan indication with high medical need.

Heitz F, La Rosa S, Gonzalez-Couto E, Gaviraghi G, Terstappen GC. Heitz F, et al. Among authors: terstappen gc. IDrugs. 2008 Sep;11(9):653-60. IDrugs. 2008. PMID: 18763216 Review.

5

Small molecule drug discovery for Huntington's Disease.

Fecke W, Gianfriddo M, Gaviraghi G, Terstappen GC, Heitz F. Fecke W, et al. Among authors: terstappen gc. Drug Discov Today. 2009 May;14(9-10):453-64. doi: 10.1016/j.drudis.2009.02.006. Epub 2009 Feb 25. Drug Discov Today. 2009. PMID: 19429504 Review.

6

Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.

Caricasole A, Bakker A, Copani A, Nicoletti F, Gaviraghi G, Terstappen GC. Caricasole A, et al. Among authors: terstappen gc. Biosci Rep. 2005 Oct-Dec;25(5-6):309-27. doi: 10.1007/s10540-005-2893-6. Biosci Rep. 2005. PMID: 16307379 Review.

7

A reporter assay for target validation in primary neuronal cultures.

Pollio G, Roncarati R, Seredenina T, Terstappen GC, Caricasole A. Pollio G, et al. Among authors: terstappen gc. J Neurosci Methods. 2008 Jul 15;172(1):34-7. doi: 10.1016/j.jneumeth.2008.03.018. Epub 2008 Apr 7. J Neurosci Methods. 2008. PMID: 18485484

8

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.

Scali C, Caraci F, Gianfriddo M, Diodato E, Roncarati R, Pollio G, Gaviraghi G, Copani A, Nicoletti F, Terstappen GC, Caricasole A. Scali C, et al. Among authors: terstappen gc. Neurobiol Dis. 2006 Nov;24(2):254-65. doi: 10.1016/j.nbd.2006.06.016. Epub 2006 Aug 17. Neurobiol Dis. 2006. PMID: 16919965

9

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.

Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F. Caricasole A, et al. Among authors: terstappen gc. J Neurosci. 2004 Jun 30;24(26):6021-7. doi: 10.1523/JNEUROSCI.1381-04.2004. J Neurosci. 2004. PMID: 15229249 Free PMC article.

10

Aryl azoles with neuroprotective activity--parallel synthesis and attempts at target identification.

Cocconcelli G, Diodato E, Caricasole A, Gaviraghi G, Genesio E, Ghiron C, Magnoni L, Pecchioli E, Plazzi PV, Terstappen GC. Cocconcelli G, et al. Among authors: terstappen gc. Bioorg Med Chem. 2008 Feb 15;16(4):2043-52. doi: 10.1016/j.bmc.2007.10.090. Epub 2007 Nov 4. Bioorg Med Chem. 2008. PMID: 18024137

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