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Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress.
Jin HO, Seo SK, Woo SH, Kim ES, Lee HC, Yoo DH, An S, Choe TB, Lee SJ, Hong SI, Rhee CH, Kim JI, Park IC. Jin HO, et al. Among authors: hong si. Free Radic Biol Med. 2009 Apr 15;46(8):1158-67. doi: 10.1016/j.freeradbiomed.2009.01.015. Epub 2009 Jan 27. Free Radic Biol Med. 2009. PMID: 19439225
Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.
Jin HO, An S, Lee HC, Woo SH, Seo SK, Choe TB, Yoo DH, Lee SB, Um HD, Lee SJ, Park MJ, Kim JI, Hong SI, Rhee CH, Park IC. Jin HO, et al. Among authors: hong si. Cell Signal. 2007 Jul;19(7):1393-403. doi: 10.1016/j.cellsig.2006.12.014. Epub 2007 Jan 20. Cell Signal. 2007. PMID: 17307335
Redd1 inhibits the invasiveness of non-small cell lung cancer cells.
Jin HO, Seo SK, Woo SH, Kim YS, Hong SE, Yi JY, Noh WC, Kim EK, Lee JK, Hong SI, Choe TB, Park IC. Jin HO, et al. Among authors: hong si, hong se. Biochem Biophys Res Commun. 2011 Apr 15;407(3):507-11. doi: 10.1016/j.bbrc.2011.03.047. Epub 2011 Mar 23. Biochem Biophys Res Commun. 2011. PMID: 21414293
Sustained overexpression of Redd1 leads to Akt activation involved in cell survival.
Jin HO, Hong SE, Kim JH, Choi HN, Kim K, An S, Choe TB, Hwang CS, Lee JH, Kim JI, Kim HA, Kim EK, Noh WC, Hong YJ, Hong SI, Lee JK, Park IC. Jin HO, et al. Among authors: hong si, hong se, hong yj. Cancer Lett. 2013 Aug 19;336(2):319-24. doi: 10.1016/j.canlet.2013.03.021. Epub 2013 Mar 22. Cancer Lett. 2013. PMID: 23528835
334 results