Han S - Search Results

1

NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.

James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V. James MF, et al. Among authors: han s. Mol Cell Biol. 2009 Aug;29(15):4250-61. doi: 10.1128/MCB.01581-08. Epub 2009 May 18. Mol Cell Biol. 2009. PMID: 19451225 Free PMC article.

2

Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling.

Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V. Han S, et al. Cell Signal. 2008 Jun;20(6):1084-91. doi: 10.1016/j.cellsig.2008.01.020. Epub 2008 Feb 1. Cell Signal. 2008. PMID: 18308511 Free PMC article.

3

Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas.

Han S, Polizzano C, Nielsen GP, Hornicek FJ, Rosenberg AE, Ramesh V. Han S, et al. Clin Cancer Res. 2009 Mar 15;15(6):1940-6. doi: 10.1158/1078-0432.CCR-08-2364. Epub 2009 Mar 10. Clin Cancer Res. 2009. PMID: 19276265 Free PMC article.

4

Regulation of mTOR complex 2 signaling in neurofibromatosis 2-deficient target cell types.

James MF, Stivison E, Beauchamp R, Han S, Li H, Wallace MR, Gusella JF, Stemmer-Rachamimov AO, Ramesh V. James MF, et al. Among authors: han s. Mol Cancer Res. 2012 May;10(5):649-59. doi: 10.1158/1541-7786.MCR-11-0425-T. Epub 2012 Mar 16. Mol Cancer Res. 2012. PMID: 22426462 Free article.

5

Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions.

Han S, Santos TM, Puga A, Roy J, Thiele EA, McCollin M, Stemmer-Rachamimov A, Ramesh V. Han S, et al. Cancer Res. 2004 Feb 1;64(3):812-6. doi: 10.1158/0008-5472.can-03-3277. Cancer Res. 2004. PMID: 14871804

6

The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.

Han S, Kim S, Bahl S, Li L, Burande CF, Smith N, James M, Beauchamp RL, Bhide P, DiAntonio A, Ramesh V. Han S, et al. J Biol Chem. 2012 Aug 31;287(36):30063-72. doi: 10.1074/jbc.M112.353987. Epub 2012 Jul 13. J Biol Chem. 2012. PMID: 22798074 Free PMC article.

7

Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.

Prabhakar S, Zhang X, Goto J, Han S, Lai C, Bronson R, Sena-Esteves M, Ramesh V, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO. Prabhakar S, et al. Among authors: han s. Neurobiol Dis. 2015 Oct;82:22-31. doi: 10.1016/j.nbd.2015.04.018. Epub 2015 May 24. Neurobiol Dis. 2015. PMID: 26019056 Free PMC article.

8

Alternative splicing in protein associated with Myc (Pam) influences its binding to c-Myc.

Santos TM, Han S, Bowser M, Sazani K, Beauchamp RL, Murthy V, Bhide PG, Ramesh V. Santos TM, et al. Among authors: han s. J Neurosci Res. 2006 Feb 1;83(2):222-32. doi: 10.1002/jnr.20723. J Neurosci Res. 2006. PMID: 16342205

9

Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex.

Murthy V, Han S, Beauchamp RL, Smith N, Haddad LA, Ito N, Ramesh V. Murthy V, et al. Among authors: han s. J Biol Chem. 2004 Jan 9;279(2):1351-8. doi: 10.1074/jbc.M310208200. Epub 2003 Oct 14. J Biol Chem. 2004. PMID: 14559897 Free article.

10

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.

Ehninger D, Han S, Shilyansky C, Zhou Y, Li W, Kwiatkowski DJ, Ramesh V, Silva AJ. Ehninger D, et al. Among authors: han s. Nat Med. 2008 Aug;14(8):843-8. doi: 10.1038/nm1788. Epub 2008 Jun 22. Nat Med. 2008. PMID: 18568033 Free PMC article.

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