Guida WC - Search Results

1

Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells.

Kazi A, Lawrence H, Guida WC, McLaughlin ML, Springett GM, Berndt N, Yip RM, Sebti SM. Kazi A, et al. Among authors: guida wc. Cell Cycle. 2009 Jun 15;8(12):1940-51. doi: 10.4161/cc.8.12.8798. Epub 2009 Jun 20. Cell Cycle. 2009. PMID: 19471122 Free PMC article.

2

Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells.

Daniel KG, Gupta P, Harbach RH, Guida WC, Dou QP. Daniel KG, et al. Among authors: guida wc. Biochem Pharmacol. 2004 Mar 15;67(6):1139-51. doi: 10.1016/j.bcp.2003.10.031. Biochem Pharmacol. 2004. PMID: 15006550

3

Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling.

Guida WC, Hamilton AD, Crotty JW, Sebti SM. Guida WC, et al. J Comput Aided Mol Des. 2005 Dec;19(12):871-85. doi: 10.1007/s10822-005-9030-2. Epub 2006 May 12. J Comput Aided Mol Des. 2005. PMID: 16607571

4

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Among authors: guida wc. Mol Pharmacol. 2006 Aug;70(2):562-70. doi: 10.1124/mol.106.025536. Epub 2006 May 22. Mol Pharmacol. 2006. PMID: 16717135

5

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Siddiquee K, et al. Among authors: guida wc. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. doi: 10.1073/pnas.0609757104. Epub 2007 Apr 26. Proc Natl Acad Sci U S A. 2007. PMID: 17463090 Free PMC article.

6

A small-molecule E2F inhibitor blocks growth in a melanoma culture model.

Ma Y, Kurtyka CA, Boyapalle S, Sung SS, Lawrence H, Guida W, Cress WD. Ma Y, et al. Cancer Res. 2008 Aug 1;68(15):6292-9. doi: 10.1158/0008-5472.CAN-08-0121. Cancer Res. 2008. PMID: 18676853 Free PMC article.

7

Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.

Lawrence HR, Pireddu R, Chen L, Luo Y, Sung SS, Szymanski AM, Yip ML, Guida WC, Sebti SM, Wu J, Lawrence NJ. Lawrence HR, et al. Among authors: guida wc. J Med Chem. 2008 Aug 28;51(16):4948-56. doi: 10.1021/jm8002526. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680359 Free PMC article.

8

Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking.

Lawrence HR, Li Z, Yip ML, Sung SS, Lawrence NJ, McLaughlin ML, McManus GJ, Zaworotko MJ, Sebti SM, Chen J, Guida WC. Lawrence HR, et al. Among authors: guida wc. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3756-9. doi: 10.1016/j.bmcl.2009.04.124. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19457663 Free PMC article.

9

Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.

Phan J, Li Z, Kasprzak A, Li B, Sebti S, Guida W, Schönbrunn E, Chen J. Phan J, et al. J Biol Chem. 2010 Jan 15;285(3):2174-83. doi: 10.1074/jbc.M109.073056. Epub 2009 Nov 12. J Biol Chem. 2010. PMID: 19910468 Free PMC article.

10

Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic alpha-helical mimics.

Anderson L, Zhou M, Sharma V, McLaughlin JM, Santiago DN, Fronczek FR, Guida WC, McLaughlin ML. Anderson L, et al. Among authors: guida wc. J Org Chem. 2010 Jun 18;75(12):4288-91. doi: 10.1021/jo100272d. J Org Chem. 2010. PMID: 20469918 Free PMC article.

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