Lawrence H - Search Results

1

Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells.

Kazi A, Lawrence H, Guida WC, McLaughlin ML, Springett GM, Berndt N, Yip RM, Sebti SM. Kazi A, et al. Among authors: lawrence h. Cell Cycle. 2009 Jun 15;8(12):1940-51. doi: 10.4161/cc.8.12.8798. Epub 2009 Jun 20. Cell Cycle. 2009. PMID: 19471122 Free PMC article.

2

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Mol Pharmacol. 2006 Aug;70(2):562-70. doi: 10.1124/mol.106.025536. Epub 2006 May 22. Mol Pharmacol. 2006. PMID: 16717135

3

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Siddiquee K, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. doi: 10.1073/pnas.0609757104. Epub 2007 Apr 26. Proc Natl Acad Sci U S A. 2007. PMID: 17463090 Free PMC article.

4

A small-molecule E2F inhibitor blocks growth in a melanoma culture model.

Ma Y, Kurtyka CA, Boyapalle S, Sung SS, Lawrence H, Guida W, Cress WD. Ma Y, et al. Among authors: lawrence h. Cancer Res. 2008 Aug 1;68(15):6292-9. doi: 10.1158/0008-5472.CAN-08-0121. Cancer Res. 2008. PMID: 18676853 Free PMC article.

5

Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.

Lawrence HR, Pireddu R, Chen L, Luo Y, Sung SS, Szymanski AM, Yip ML, Guida WC, Sebti SM, Wu J, Lawrence NJ. Lawrence HR, et al. J Med Chem. 2008 Aug 28;51(16):4948-56. doi: 10.1021/jm8002526. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680359 Free PMC article.

6

Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking.

Lawrence HR, Li Z, Yip ML, Sung SS, Lawrence NJ, McLaughlin ML, McManus GJ, Zaworotko MJ, Sebti SM, Chen J, Guida WC. Lawrence HR, et al. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3756-9. doi: 10.1016/j.bmcl.2009.04.124. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19457663 Free PMC article.

7

Targeting protein tyrosine phosphatases for anticancer drug discovery.

Scott LM, Lawrence HR, Sebti SM, Lawrence NJ, Wu J. Scott LM, et al. Curr Pharm Des. 2010 Jun;16(16):1843-62. doi: 10.2174/138161210791209027. Curr Pharm Des. 2010. PMID: 20337577 Free PMC article. Review.

8

Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.

Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Biochem Pharmacol. 2010 Sep 15;80(6):801-10. doi: 10.1016/j.bcp.2010.05.019. Epub 2010 May 25. Biochem Pharmacol. 2010. PMID: 20510203 Free PMC article.

9

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors.

Lawrence HR, Kazi A, Luo Y, Kendig R, Ge Y, Jain S, Daniel K, Santiago D, Guida WC, Sebti SM. Lawrence HR, et al. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. doi: 10.1016/j.bmc.2010.06.038. Epub 2010 Jun 18. Bioorg Med Chem. 2010. PMID: 20621484 Free PMC article.

10

Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.

Scott LM, Chen L, Daniel KG, Brooks WH, Guida WC, Lawrence HR, Sebti SM, Lawrence NJ, Wu J. Scott LM, et al. Among authors: lawrence nj, lawrence hr. Bioorg Med Chem Lett. 2011 Jan 15;21(2):730-3. doi: 10.1016/j.bmcl.2010.11.117. Epub 2010 Dec 4. Bioorg Med Chem Lett. 2011. PMID: 21193311 Free PMC article.

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