McLaughlin ML - Search Results

1

Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells.

Kazi A, Lawrence H, Guida WC, McLaughlin ML, Springett GM, Berndt N, Yip RM, Sebti SM. Kazi A, et al. Among authors: mclaughlin ml. Cell Cycle. 2009 Jun 15;8(12):1940-51. doi: 10.4161/cc.8.12.8798. Epub 2009 Jun 20. Cell Cycle. 2009. PMID: 19471122 Free PMC article.

2

Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking.

Lawrence HR, Li Z, Yip ML, Sung SS, Lawrence NJ, McLaughlin ML, McManus GJ, Zaworotko MJ, Sebti SM, Chen J, Guida WC. Lawrence HR, et al. Among authors: mclaughlin ml. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3756-9. doi: 10.1016/j.bmcl.2009.04.124. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19457663 Free PMC article.

3

Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic alpha-helical mimics.

Anderson L, Zhou M, Sharma V, McLaughlin JM, Santiago DN, Fronczek FR, Guida WC, McLaughlin ML. Anderson L, et al. Among authors: mclaughlin ml, mclaughlin jm. J Org Chem. 2010 Jun 18;75(12):4288-91. doi: 10.1021/jo100272d. J Org Chem. 2010. PMID: 20469918 Free PMC article.

4

Bioactivity improvement via display of the hydrophobic core of HYD1 in a cyclic β-hairpin-like scaffold, MTI-101.

Jain P, Badger DB, Liang Y, Gebhard AW, Santiago D, Murray P, Kaulagari SR, Gauthier TJ, Nair R, Kumar M, Guida WC, Hazlehurst LA, McLaughlin ML. Jain P, et al. Among authors: mclaughlin ml. Pept Sci (Hoboken). 2021 May;113(3):e24199. doi: 10.1002/pep2.24199. Epub 2020 Oct 9. Pept Sci (Hoboken). 2021. PMID: 35859761 Free PMC article.

5

Cysteine based PNA (CPNA): design and synthesis of novel CPNA monomers.

Yi SW, Jain P, Ajmera M, Kaulagari SR, Topper M, Anderson L, McLaughlin ML. Yi SW, et al. Among authors: mclaughlin ml. Adv Exp Med Biol. 2009;611:553-4. doi: 10.1007/978-0-387-73657-0_243. Adv Exp Med Biol. 2009. PMID: 19400310 No abstract available.

6

Acquisition of resistance toward HYD1 correlates with a reduction in cleaved α4 integrin expression and a compromised CAM-DR phenotype.

Emmons MF, Gebhard AW, Nair RR, Baz R, McLaughlin ML, Cress AE, Hazlehurst LA. Emmons MF, et al. Among authors: mclaughlin ml. Mol Cancer Ther. 2011 Dec;10(12):2257-66. doi: 10.1158/1535-7163.MCT-11-0149. Epub 2011 Oct 6. Mol Cancer Ther. 2011. PMID: 21980133 Free PMC article.

7

MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myeloma.

Gebhard AW, Jain P, Nair RR, Emmons MF, Argilagos RF, Koomen JM, McLaughlin ML, Hazlehurst LA. Gebhard AW, et al. Among authors: mclaughlin ml. Mol Cancer Ther. 2013 Nov;12(11):2446-58. doi: 10.1158/1535-7163.MCT-13-0310. Epub 2013 Sep 18. Mol Cancer Ther. 2013. PMID: 24048737 Free PMC article.

8

Intraoperative Guidance of Pancreatic Cancer Resection Using a Toll-like Receptor 2-Targeted Fluorescence Molecular Imaging Agent.

Huynh AS, Cohen AS, Doligalski M, Casagni TJ, Moberg VE, Huang X, Morse J, Abrahams D, Lloyd MC, Centeno BA, Baldwin MK, McLaughlin ML, Vagner J, Morse DL. Huynh AS, et al. Among authors: mclaughlin ml. Cancer Res Commun. 2024 Nov 1;4(11):2877-2887. doi: 10.1158/2767-9764.CRC-24-0244. Cancer Res Commun. 2024. PMID: 39320054 Free PMC article.

9

Efficient assembly of 2,5,6-substituted pyrimidines via MgI(2)-mediated Morita-Baylis-Hillman reaction.

Sharma V, McLaughlin ML. Sharma V, et al. Among authors: mclaughlin ml. J Comb Chem. 2010 May 10;12(3):327-31. doi: 10.1021/cc100001e. J Comb Chem. 2010. PMID: 20218627 Free PMC article.

10

Synthesis of N-Boc protected hydrazine diacids as key structural units for the formation of alpha-helix mimics.

Anderson L, Topper M, Jain P, McIntosh E, McLaughlin ML. Anderson L, et al. Among authors: mclaughlin ml. Adv Exp Med Biol. 2009;611:211-2. doi: 10.1007/978-0-387-73657-0_97. Adv Exp Med Biol. 2009. PMID: 19400164 No abstract available.

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