Girijavallabhan V - Search Results

1

Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.

Venkatraman S, Blackman M, Wu W, Nair L, Arasappan A, Padilla A, Bogen S, Bennett F, Chen K, Pichardo J, Tong X, Prongay A, Cheng KC, Girijavallabhan V, George Njoroge F. Venkatraman S, et al. Among authors: girijavallabhan v. Bioorg Med Chem. 2009 Jul 1;17(13):4486-95. doi: 10.1016/j.bmc.2009.05.012. Epub 2009 May 9. Bioorg Med Chem. 2009. PMID: 19481946

2

Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design.

Venkatraman S, Njoroge FG, Girijavallabhan VM, Madison VS, Yao NH, Prongay AJ, Butkiewicz N, Pichardo J. Venkatraman S, et al. J Med Chem. 2005 Aug 11;48(16):5088-91. doi: 10.1021/jm0489556. J Med Chem. 2005. PMID: 16078825

3

The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.

Bennett F, Huang Y, Hendrata S, Lovey R, Bogen SL, Pan W, Guo Z, Prongay A, Chen KX, Arasappan A, Venkatraman S, Velazquez F, Nair L, Sannigrahi M, Tong X, Pichardo J, Cheng KC, Girijavallabhan VM, Saksena AK, Njoroge FG. Bennett F, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2617-21. doi: 10.1016/j.bmcl.2010.02.063. Epub 2010 Feb 19. Bioorg Med Chem Lett. 2010. PMID: 20303756

4

Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex.

Arasappan A, Njoroge FG, Parekh TN, Yang X, Pichardo J, Butkiewicz N, Prongay A, Yao N, Girijavallabhan V. Arasappan A, et al. Among authors: girijavallabhan v. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5751-5. doi: 10.1016/j.bmcl.2004.09.058. Bioorg Med Chem Lett. 2004. PMID: 15501035

5

Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease.

Chen KX, Njoroge FG, Prongay A, Pichardo J, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: girijavallabhan v. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4475-8. doi: 10.1016/j.bmcl.2005.07.033. Bioorg Med Chem Lett. 2005. PMID: 16112859

6

Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease.

Chen KX, Njoroge FG, Pichardo J, Prongay A, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: girijavallabhan v. J Med Chem. 2005 Oct 6;48(20):6229-35. doi: 10.1021/jm050323b. J Med Chem. 2005. PMID: 16190750

7

Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.

Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG. Bogen SL, et al. Among authors: girijavallabhan v. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. doi: 10.1016/j.bmcl.2005.12.013. Epub 2006 Jan 4. Bioorg Med Chem Lett. 2006. PMID: 16387495

8

Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid.

Venkatraman S, Njoroge FG, Wu W, Girijavallabhan V, Prongay AJ, Butkiewicz N, Pichardo J. Venkatraman S, et al. Among authors: girijavallabhan v. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1628-32. doi: 10.1016/j.bmcl.2005.12.046. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413182

9

Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease.

Chen KX, Njoroge FG, Pichardo J, Prongay A, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: girijavallabhan v. J Med Chem. 2006 Jan 26;49(2):567-74. doi: 10.1021/jm050520a. J Med Chem. 2006. PMID: 16420042

10

Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.

Chen KX, Njoroge FG, Arasappan A, Venkatraman S, Vibulbhan B, Yang W, Parekh TN, Pichardo J, Prongay A, Cheng KC, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: girijavallabhan v. J Med Chem. 2006 Feb 9;49(3):995-1005. doi: 10.1021/jm050820s. J Med Chem. 2006. PMID: 16451065

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