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Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug.
Hayashi S, Hirao A, Imai A, Nakamura H, Murata Y, Ohashi K, Nakata E. Hayashi S, et al. Among authors: nakata e. J Med Chem. 2009 Feb 12;52(3):610-25. doi: 10.1021/jm7012979. J Med Chem. 2009. PMID: 19125610
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.
Hayashi S, Nakata E, Morita A, Mizuno K, Yamamura K, Kato A, Ohashi K. Hayashi S, et al. Among authors: nakata e. Bioorg Med Chem. 2010 Nov 1;18(21):7675-99. doi: 10.1016/j.bmc.2010.07.034. Epub 2010 Jul 21. Bioorg Med Chem. 2010. PMID: 20875743
Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure-activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives.
Hayashi S, Ohashi K, Mihara S, Nakata E, Emoto C, Ohta A. Hayashi S, et al. Among authors: nakata e. Eur J Med Chem. 2016 May 23;114:345-64. doi: 10.1016/j.ejmech.2016.02.014. Epub 2016 Feb 6. Eur J Med Chem. 2016. PMID: 27043173
Novel delta opioid receptor agonists with oxazatricyclodecane structure.
Fujii H, Hayashida K, Saitoh A, Yokoyama A, Hirayama S, Iwai T, Nakata E, Nemoto T, Sudo Y, Uezono Y, Yamada M, Nagase H. Fujii H, et al. Among authors: nakata e. ACS Med Chem Lett. 2014 Jan 27;5(4):368-72. doi: 10.1021/ml400491k. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900842 Free PMC article.
230 results