Carfí A - Search Results

1

Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.

Rydberg EH, Cellucci A, Bartholomew L, Mattu M, Barbato G, Ludmerer SW, Graham DJ, Altamura S, Paonessa G, De Francesco R, Migliaccio G, Carfí A. Rydberg EH, et al. Among authors: carfi a. J Mol Biol. 2009 Jul 31;390(5):1048-59. doi: 10.1016/j.jmb.2009.06.012. Epub 2009 Jun 6. J Mol Biol. 2009. PMID: 19505479

2

Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

De Francesco R, Carfí A. De Francesco R, et al. Among authors: carfi a. Adv Drug Deliv Rev. 2007 Oct 10;59(12):1242-62. doi: 10.1016/j.addr.2007.04.016. Epub 2007 Aug 11. Adv Drug Deliv Rev. 2007. PMID: 17869377 Review.

3

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.

Ontoria JM, Rydberg EH, Di Marco S, Tomei L, Attenni B, Malancona S, Martin Hernando JI, Gennari N, Koch U, Narjes F, Rowley M, Summa V, Carroll SS, Olsen DB, De Francesco R, Altamura S, Migliaccio G, Carfì A. Ontoria JM, et al. Among authors: carfi a. J Med Chem. 2009 Aug 27;52(16):5217-27. doi: 10.1021/jm900517t. J Med Chem. 2009. PMID: 19877603

4

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site.

Di Marco S, Volpari C, Tomei L, Altamura S, Harper S, Narjes F, Koch U, Rowley M, De Francesco R, Migliaccio G, Carfí A. Di Marco S, et al. Among authors: carfi a. J Biol Chem. 2005 Aug 19;280(33):29765-70. doi: 10.1074/jbc.M505423200. Epub 2005 Jun 13. J Biol Chem. 2005. PMID: 15955819 Free article.

5

Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.

Luftig MA, Mattu M, Di Giovine P, Geleziunas R, Hrin R, Barbato G, Bianchi E, Miller MD, Pessi A, Carfí A. Luftig MA, et al. Among authors: carfi a. Nat Struct Mol Biol. 2006 Aug;13(8):740-7. doi: 10.1038/nsmb1127. Epub 2006 Jul 23. Nat Struct Mol Biol. 2006. PMID: 16862157

6

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.

Vannini A, Volpari C, Gallinari P, Jones P, Mattu M, Carfí A, De Francesco R, Steinkühler C, Di Marco S. Vannini A, et al. Among authors: carfi a. EMBO Rep. 2007 Sep;8(9):879-84. doi: 10.1038/sj.embor.7401047. Epub 2007 Aug 10. EMBO Rep. 2007. PMID: 17721440 Free PMC article.

7

Development and optimization of a binding assay for histone deacetylase 4 using surface plasmon resonance.

Mattu M, Di Giovine P, Steinkuhler C, De Francesco R, Altamura S, Cecchetti O, Carfì A, Barbato G. Mattu M, et al. Among authors: carfi a. Anal Biochem. 2008 Jun 15;377(2):267-9. doi: 10.1016/j.ab.2008.03.028. Epub 2008 Mar 22. Anal Biochem. 2008. PMID: 18381195

8

Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.

Harper S, Avolio S, Pacini B, Di Filippo M, Altamura S, Tomei L, Paonessa G, Di Marco S, Carfi A, Giuliano C, Padron J, Bonelli F, Migliaccio G, De Francesco R, Laufer R, Rowley M, Narjes F. Harper S, et al. Among authors: carfi a. J Med Chem. 2005 Jul 14;48(14):4547-57. doi: 10.1021/jm050056+. J Med Chem. 2005. PMID: 15999993

9

Preparation and handling of hepatitis C viral proteins NS3 and NS5B for structural studies.

Marco SD, Carfí A. Marco SD, et al. Among authors: carfi a. Methods Mol Biol. 2009;510:111-24. doi: 10.1007/978-1-59745-394-3_9. Methods Mol Biol. 2009. PMID: 19009257

10

Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants.

Bottomley MJ, Cirillo A, Orsatti L, Ruggeri L, Fisher TS, Santoro JC, Cummings RT, Cubbon RM, Lo Surdo P, Calzetta A, Noto A, Baysarowich J, Mattu M, Talamo F, De Francesco R, Sparrow CP, Sitlani A, Carfí A. Bottomley MJ, et al. Among authors: carfi a. J Biol Chem. 2009 Jan 9;284(2):1313-23. doi: 10.1074/jbc.M808363200. Epub 2008 Nov 10. J Biol Chem. 2009. PMID: 19001363 Free article.

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