Niwa R - Search Results

1

Engineered therapeutic antibodies with improved effector functions.

Kubota T, Niwa R, Satoh M, Akinaga S, Shitara K, Hanai N. Kubota T, et al. Among authors: niwa r. Cancer Sci. 2009 Sep;100(9):1566-72. doi: 10.1111/j.1349-7006.2009.01222.x. Epub 2009 May 18. Cancer Sci. 2009. PMID: 19538497 Free PMC article. Review.

2

Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma.

Niwa R, Shoji-Hosaka E, Sakurada M, Shinkawa T, Uchida K, Nakamura K, Matsushima K, Ueda R, Hanai N, Shitara K. Niwa R, et al. Cancer Res. 2004 Mar 15;64(6):2127-33. doi: 10.1158/0008-5472.can-03-2068. Cancer Res. 2004. PMID: 15026353

3

Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA.

Mori K, Kuni-Kamochi R, Yamane-Ohnuki N, Wakitani M, Yamano K, Imai H, Kanda Y, Niwa R, Iida S, Uchida K, Shitara K, Satoh M. Mori K, et al. Among authors: niwa r. Biotechnol Bioeng. 2004 Dec 30;88(7):901-8. doi: 10.1002/bit.20326. Biotechnol Bioeng. 2004. PMID: 15515168

4

Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities.

Natsume A, In M, Takamura H, Nakagawa T, Shimizu Y, Kitajima K, Wakitani M, Ohta S, Satoh M, Shitara K, Niwa R. Natsume A, et al. Among authors: niwa r. Cancer Res. 2008 May 15;68(10):3863-72. doi: 10.1158/0008-5472.CAN-07-6297. Cancer Res. 2008. PMID: 18483271

5

Engineered anti-CD20 antibodies with enhanced complement-activating capacity mediate potent anti-lymphoma activity.

Natsume A, Shimizu-Yokoyama Y, Satoh M, Shitara K, Niwa R. Natsume A, et al. Among authors: niwa r. Cancer Sci. 2009 Dec;100(12):2411-8. doi: 10.1111/j.1349-7006.2009.01327.x. Epub 2009 Aug 25. Cancer Sci. 2009. PMID: 19758394 Free PMC article.

6

The current status and prospects of antibody engineering for therapeutic use: focus on glycoengineering technology.

Niwa R, Satoh M. Niwa R, et al. J Pharm Sci. 2015 Mar;104(3):930-41. doi: 10.1002/jps.24316. Epub 2015 Jan 12. J Pharm Sci. 2015. PMID: 25583555 Review.

7

Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity.

Yamane-Ohnuki N, Kinoshita S, Inoue-Urakubo M, Kusunoki M, Iida S, Nakano R, Wakitani M, Niwa R, Sakurada M, Uchida K, Shitara K, Satoh M. Yamane-Ohnuki N, et al. Among authors: niwa r. Biotechnol Bioeng. 2004 Sep 5;87(5):614-22. doi: 10.1002/bit.20151. Biotechnol Bioeng. 2004. PMID: 15352059

8

Enhancement of the antibody-dependent cellular cytotoxicity of low-fucose IgG1 Is independent of FcgammaRIIIa functional polymorphism.

Niwa R, Hatanaka S, Shoji-Hosaka E, Sakurada M, Kobayashi Y, Uehara A, Yokoi H, Nakamura K, Shitara K. Niwa R, et al. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6248-55. doi: 10.1158/1078-0432.CCR-04-0850. Clin Cancer Res. 2004. PMID: 15448014

9

Enhanced natural killer cell binding and activation by low-fucose IgG1 antibody results in potent antibody-dependent cellular cytotoxicity induction at lower antigen density.

Niwa R, Sakurada M, Kobayashi Y, Uehara A, Matsushima K, Ueda R, Nakamura K, Shitara K. Niwa R, et al. Clin Cancer Res. 2005 Mar 15;11(6):2327-36. doi: 10.1158/1078-0432.CCR-04-2263. Clin Cancer Res. 2005. PMID: 15788684

10

IgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharides.

Niwa R, Natsume A, Uehara A, Wakitani M, Iida S, Uchida K, Satoh M, Shitara K. Niwa R, et al. J Immunol Methods. 2005 Nov 30;306(1-2):151-60. doi: 10.1016/j.jim.2005.08.009. Epub 2005 Sep 22. J Immunol Methods. 2005. PMID: 16219319

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