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Regulation of lipopolysaccharide-induced inducible nitric-oxide synthase expression through the nuclear factor-kappaB pathway and interferon-beta/tyrosine kinase 2/Janus tyrosine kinase 2-signal transducer and activator of transcription-1 signaling cascades by 2-naphthylethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (THI 53), a new synthetic isoquinoline alkaloid.
Kim HJ, Tsoyi K, Heo JM, Kang YJ, Park MK, Lee YS, Lee JH, Seo HG, Yun-Choi HS, Chang KC. Kim HJ, et al. Among authors: chang kc. J Pharmacol Exp Ther. 2007 Feb;320(2):782-9. doi: 10.1124/jpet.106.112052. Epub 2006 Nov 15. J Pharmacol Exp Ther. 2007. PMID: 17108235
YS 51, 1-(beta-naphtylmethyl)-6,7-dihydroxy-1,2,3,4,-tetrahydroisoquinoline, protects endothelial cells against hydrogen peroxide-induced injury via carbon monoxide derived from heme oxygenase-1.
Heo JM, Kim HJ, Ha YM, Park MK, Kang YJ, Lee YS, Seo HG, Lee JH, Yun-Choi HS, Chang KC. Heo JM, et al. Among authors: chang kc. Biochem Pharmacol. 2007 Nov 1;74(9):1361-70. doi: 10.1016/j.bcp.2007.07.023. Epub 2007 Jul 21. Biochem Pharmacol. 2007. PMID: 17719563
Heme oxygenase-1 induction by (S)-enantiomer of YS-51 (YS-51S), a synthetic isoquinoline alkaloid, inhibits nitric oxide production and nuclear factor-kappaB translocation in ROS 17/2.8 cells activated with inflammatory stimulants.
Chaea HJ, Kim HR, Kang YJ, Hyun KC, Kim HJ, Seo HG, Lee JH, Yun-Choi HS, Chang KC. Chaea HJ, et al. Among authors: chang kc. Int Immunopharmacol. 2007 Dec 5;7(12):1559-68. doi: 10.1016/j.intimp.2007.07.023. Epub 2007 Aug 14. Int Immunopharmacol. 2007. PMID: 17920533
HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.
Tsoyi K, Kim HJ, Shin JS, Kim DH, Cho HJ, Lee SS, Ahn SK, Yun-Choi HS, Lee JH, Seo HG, Chang KC. Tsoyi K, et al. Among authors: chang kc. Cell Signal. 2008 Oct;20(10):1839-47. doi: 10.1016/j.cellsig.2008.06.012. Epub 2008 Jun 27. Cell Signal. 2008. PMID: 18634870
Rutin from Lonicera japonica inhibits myocardial ischemia/reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro.
Jeong JJ, Ha YM, Jin YC, Lee EJ, Kim JS, Kim HJ, Seo HG, Lee JH, Kang SS, Kim YS, Chang KC. Jeong JJ, et al. Among authors: chang kc. Food Chem Toxicol. 2009 Jul;47(7):1569-76. doi: 10.1016/j.fct.2009.03.044. Epub 2009 Apr 9. Food Chem Toxicol. 2009. PMID: 19362115
Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-alpha-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo.
Jin YC, Kim CW, Kim YM, Nizamutdinova IT, Ha YM, Kim HJ, Seo HG, Son KH, Jeon SJ, Kang SS, Kim YS, Kam SC, Lee JH, Chang KC. Jin YC, et al. Among authors: chang kc. Eur J Pharmacol. 2009 Jul 1;614(1-3):91-7. doi: 10.1016/j.ejphar.2009.04.038. Epub 2009 May 3. Eur J Pharmacol. 2009. PMID: 19401198
(S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) reduces rat myocardial apoptosis against ischemia and reperfusion injury by activation of phosphatidylinositol 3-kinase/Akt signaling and anti-inflammatory action in vivo.
Jin YC, Lee YS, Kim YM, Seo HG, Lee JH, Kim HJ, Yun-Choi HS, Chang KC. Jin YC, et al. Among authors: chang kc. J Pharmacol Exp Ther. 2009 Aug;330(2):440-8. doi: 10.1124/jpet.108.150342. Epub 2009 May 20. J Pharmacol Exp Ther. 2009. PMID: 19458286
1,769 results