Tsai YC - Search Results

1

Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.

Das R, Mariano J, Tsai YC, Kalathur RC, Kostova Z, Li J, Tarasov SG, McFeeters RL, Altieri AS, Ji X, Byrd RA, Weissman AM. Das R, et al. Among authors: tsai yc. Mol Cell. 2009 Jun 26;34(6):674-85. doi: 10.1016/j.molcel.2009.05.010. Mol Cell. 2009. PMID: 19560420 Free PMC article.

2

The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site.

Chen B, Mariano J, Tsai YC, Chan AH, Cohen M, Weissman AM. Chen B, et al. Among authors: tsai yc. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):341-6. doi: 10.1073/pnas.0506618103. Epub 2006 Jan 3. Proc Natl Acad Sci U S A. 2006. PMID: 16407162 Free PMC article.

3

The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain.

Mattera R, Tsai YC, Weissman AM, Bonifacino JS. Mattera R, et al. Among authors: tsai yc. J Biol Chem. 2006 Mar 10;281(10):6874-83. doi: 10.1074/jbc.M509939200. Epub 2006 Jan 5. J Biol Chem. 2006. PMID: 16407276 Free article.

4

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.

Lee S, Tsai YC, Mattera R, Smith WJ, Kostelansky MS, Weissman AM, Bonifacino JS, Hurley JH. Lee S, et al. Among authors: tsai yc. Nat Struct Mol Biol. 2006 Mar;13(3):264-71. doi: 10.1038/nsmb1064. Epub 2006 Feb 5. Nat Struct Mol Biol. 2006. PMID: 16462746 Free PMC article.

5

RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.

Brauweiler A, Lorick KL, Lee JP, Tsai YC, Chan D, Weissman AM, Drabkin HA, Gemmill RM. Brauweiler A, et al. Among authors: tsai yc. Oncogene. 2007 Apr 5;26(16):2263-71. doi: 10.1038/sj.onc.1210017. Epub 2006 Oct 2. Oncogene. 2007. PMID: 17016439

6

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

Yang Y, Kitagaki J, Dai RM, Tsai YC, Lorick KL, Ludwig RL, Pierre SA, Jensen JP, Davydov IV, Oberoi P, Li CC, Kenten JH, Beutler JA, Vousden KH, Weissman AM. Yang Y, et al. Among authors: tsai yc. Cancer Res. 2007 Oct 1;67(19):9472-81. doi: 10.1158/0008-5472.CAN-07-0568. Cancer Res. 2007. PMID: 17909057

7

Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation.

Kostova Z, Tsai YC, Weissman AM. Kostova Z, et al. Among authors: tsai yc. Semin Cell Dev Biol. 2007 Dec;18(6):770-9. doi: 10.1016/j.semcdb.2007.09.002. Epub 2007 Sep 8. Semin Cell Dev Biol. 2007. PMID: 17950636 Free PMC article. Review.

8

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.

Tsai YC, Mendoza A, Mariano JM, Zhou M, Kostova Z, Chen B, Veenstra T, Hewitt SM, Helman LJ, Khanna C, Weissman AM. Tsai YC, et al. Nat Med. 2007 Dec;13(12):1504-9. doi: 10.1038/nm1686. Epub 2007 Nov 25. Nat Med. 2007. PMID: 18037895

9

Differences in the tumor microenvironment between African-American and European-American breast cancer patients.

Martin DN, Boersma BJ, Yi M, Reimers M, Howe TM, Yfantis HG, Tsai YC, Williams EH, Lee DH, Stephens RM, Weissman AM, Ambs S. Martin DN, et al. Among authors: tsai yc. PLoS One. 2009;4(2):e4531. doi: 10.1371/journal.pone.0004531. Epub 2009 Feb 19. PLoS One. 2009. PMID: 19225562 Free PMC article.

10

Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum.

Shmueli A, Tsai YC, Yang M, Braun MA, Weissman AM. Shmueli A, et al. Among authors: tsai yc. Biochem Biophys Res Commun. 2009 Dec 18;390(3):758-62. doi: 10.1016/j.bbrc.2009.10.045. Epub 2009 Oct 14. Biochem Biophys Res Commun. 2009. PMID: 19835843 Free PMC article.

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