van Leuven F - Search Results

1

Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels.

Jansen PJ, Lütjohann D, Thelen KM, von Bergmann K, van Leuven F, Ramaekers FC, Monique M. Jansen PJ, et al. Among authors: van leuven f. J Alzheimers Dis. 2009;18(2):319-29. doi: 10.3233/JAD-2009-1150. J Alzheimers Dis. 2009. PMID: 19584433

2

Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.

Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J. Tamboli IY, et al. Among authors: van leuven f. J Neurosci. 2008 Nov 12;28(46):12097-106. doi: 10.1523/JNEUROSCI.2635-08.2008. J Neurosci. 2008. PMID: 19005074 Free PMC article.

3

BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid.

Barao S, Zhou L, Adamczuk K, Vanhoutvin T, van Leuven F, Demedts D, Vijverman AC, Bossuyt X, Vandenberghe R, De Strooper B. Barao S, et al. Among authors: van leuven f. Curr Alzheimer Res. 2013 Sep;10(7):671-8. doi: 10.2174/15672050113109990138. Curr Alzheimer Res. 2013. PMID: 23566348

4

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.

Kukreja L, Kujoth GC, Prolla TA, Van Leuven F, Vassar R. Kukreja L, et al. Among authors: van leuven f. Mol Neurodegener. 2014 May 2;9:16. doi: 10.1186/1750-1326-9-16. Mol Neurodegener. 2014. PMID: 24885175 Free PMC article.

5

Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope.

Theunis C, Adolfsson O, Crespo-Biel N, Piorkowska K, Pihlgren M, Hickman DT, Gafner V, Borghgraef P, Devijver H, Pfeifer A, Van Leuven F, Muhs A. Theunis C, et al. Among authors: van leuven f. J Alzheimers Dis. 2017;56(2):585-599. doi: 10.3233/JAD-160695. J Alzheimers Dis. 2017. PMID: 28035925 Free PMC article.

6

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

Sastre M, Dewachter I, Landreth GE, Willson TM, Klockgether T, van Leuven F, Heneka MT. Sastre M, et al. Among authors: van leuven f. J Neurosci. 2003 Oct 29;23(30):9796-804. doi: 10.1523/JNEUROSCI.23-30-09796.2003. J Neurosci. 2003. PMID: 14586007 Free PMC article.

7

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.

Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT. Sastre M, et al. Among authors: van leuven f. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):443-8. doi: 10.1073/pnas.0503839103. Epub 2006 Jan 3. Proc Natl Acad Sci U S A. 2006. PMID: 16407166 Free PMC article.

8

Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo.

Hirata-Fukae C, Sidahmed EH, Gooskens TP, Aisen PS, Dewachter I, Devijver H, Van Leuven F, Matsuoka Y. Hirata-Fukae C, et al. Among authors: van leuven f. Neurosci Lett. 2008 Apr 25;435(3):186-9. doi: 10.1016/j.neulet.2008.02.032. Epub 2008 Mar 10. Neurosci Lett. 2008. PMID: 18343582 Free PMC article.

9

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease.

Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR. Rolyan H, et al. Among authors: van leuven f, van dooren t. J Neural Transm (Vienna). 2011 May;118(5):699-712. doi: 10.1007/s00702-010-0572-7. Epub 2011 Jan 6. J Neural Transm (Vienna). 2011. PMID: 21210284

10

Secretases as targets for the treatment of Alzheimer's disease: the prospects.

Dewachter I, Van Leuven F. Dewachter I, et al. Among authors: van leuven f. Lancet Neurol. 2002 Nov;1(7):409-16. doi: 10.1016/s1474-4422(02)00188-6. Lancet Neurol. 2002. PMID: 12849363 Review.

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