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Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions.
Shahriar M, Mizuguchi H, Maeyama K, Kitamura Y, Orimoto N, Horio S, Umehara H, Hattori M, Takeda N, Fukui H. Shahriar M, et al. Among authors: hattori m. J Immunol. 2009 Aug 1;183(3):2133-41. doi: 10.4049/jimmunol.0901058. Epub 2009 Jul 13. J Immunol. 2009. PMID: 19596986
Preseasonal prophylactic treatment with antihistamines suppresses nasal symptoms and expression of histamine H₁ receptor mRNA in the nasal mucosa of patients with pollinosis.
Mizuguchi H, Kitamura Y, Kondo Y, Kuroda W, Yoshida H, Miyamoto Y, Hattori M, Fukui H, Takeda N. Mizuguchi H, et al. Among authors: hattori m. Methods Find Exp Clin Pharmacol. 2010 Dec;32(10):745-8. doi: 10.1358/mf.2010.32.10.1533687. Methods Find Exp Clin Pharmacol. 2010. PMID: 21225011 Free article. Clinical Trial.
Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells.
Hattori M, Mizuguchi H, Baba Y, Ono S, Nakano T, Zhang Q, Sasaki Y, Kobayashi M, Kitamura Y, Takeda N, Fukui H. Hattori M, et al. Int Immunopharmacol. 2013 Feb;15(2):232-9. doi: 10.1016/j.intimp.2012.12.030. Epub 2013 Jan 16. Int Immunopharmacol. 2013. PMID: 23333628
2,638 results