Berndt A - Search Results

1

Form and flexibility in phosphoinositide 3-kinases.

Williams R, Berndt A, Miller S, Hon WC, Zhang X. Williams R, et al. Among authors: berndt a. Biochem Soc Trans. 2009 Aug;37(Pt 4):615-26. doi: 10.1042/BST0370615. Biochem Soc Trans. 2009. PMID: 19614567 Review.

2

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases.

Hon WC, Berndt A, Williams RL. Hon WC, et al. Among authors: berndt a. Oncogene. 2012 Aug 9;31(32):3655-66. doi: 10.1038/onc.2011.532. Epub 2011 Nov 28. Oncogene. 2012. PMID: 22120714 Free PMC article.

3

The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, Williams RL. Berndt A, et al. Nat Chem Biol. 2010 Feb;6(2):117-24. doi: 10.1038/nchembio.293. Nat Chem Biol. 2010. PMID: 20081827 Free PMC article.

4

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases.

Vadas O, Burke JE, Zhang X, Berndt A, Williams RL. Vadas O, et al. Among authors: berndt a. Sci Signal. 2011 Oct 18;4(195):re2. doi: 10.1126/scisignal.2002165. Sci Signal. 2011. PMID: 22009150 Review.

5

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.

Burke JE, Vadas O, Berndt A, Finegan T, Perisic O, Williams RL. Burke JE, et al. Among authors: berndt a. Structure. 2011 Aug 10;19(8):1127-37. doi: 10.1016/j.str.2011.06.003. Structure. 2011. PMID: 21827948 Free PMC article.

6

Tor forms a dimer through an N-terminal helical solenoid with a complex topology.

Baretić D, Berndt A, Ohashi Y, Johnson CM, Williams RL. Baretić D, et al. Among authors: berndt a. Nat Commun. 2016 Apr 13;7:11016. doi: 10.1038/ncomms11016. Nat Commun. 2016. PMID: 27072897 Free PMC article.

7

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC. Pirali T, et al. Among authors: berndt a. ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31. ChemMedChem. 2017. PMID: 28857471 Free PMC article.

8

Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Anandapadamanaban M, Masson GR, Perisic O, Berndt A, Kaufman J, Johnson CM, Santhanam B, Rogala KB, Sabatini DM, Williams RL. Anandapadamanaban M, et al. Among authors: berndt a. Science. 2019 Oct 11;366(6462):203-210. doi: 10.1126/science.aax3939. Science. 2019. PMID: 31601764 Free PMC article.

9

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.

Heimhalt M, Berndt A, Wagstaff J, Anandapadamanaban M, Perisic O, Maslen S, McLaughlin S, Yu CW, Masson GR, Boland A, Ni X, Yamashita K, Murshudov GN, Skehel M, Freund SM, Williams RL. Heimhalt M, et al. Among authors: berndt a. Elife. 2021 Sep 14;10:e68799. doi: 10.7554/eLife.68799. Elife. 2021. PMID: 34519269 Free PMC article.

10

The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, Williams RL. Berndt A, et al. Nat Chem Biol. 2010 Mar;6(3):244. doi: 10.1038/nchembio0310-244b. Nat Chem Biol. 2010. PMID: 20154668 No abstract available.

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