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Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.
Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, Bara T, Engstrom L, Pinzon-Ortiz M, Fine JS, Lee HJ, Zhang L, Higgins GA, Parker EM. Wong GT, et al. Among authors: engstrom l. J Biol Chem. 2004 Mar 26;279(13):12876-82. doi: 10.1074/jbc.M311652200. Epub 2004 Jan 6. J Biol Chem. 2004. PMID: 14709552 Free article.
Drug-induced hemolytic anemia and thrombocytopenia associated with alterations of cell membrane lipids and acanthocyte formation.
Poulet FM, Penraat K, Collins N, Evans E, Thackaberry E, Manfra D, Engstrom L, Geissler R, Geraci-Erck M, Frugone C, Abutarif M, Fine JS, Peterson BL, Cummings BS, Johnson RC. Poulet FM, et al. Among authors: engstrom l. Toxicol Pathol. 2010 Oct;38(6):907-22. doi: 10.1177/0192623310378865. Epub 2010 Aug 30. Toxicol Pathol. 2010. PMID: 20805317
Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity.
Guo Y, MacIsaac KD, Chen Y, Miller RJ, Jain R, Joyce-Shaikh B, Ferguson H, Wang IM, Cristescu R, Mudgett J, Engstrom L, Piers KJ, Baltus GA, Barr K, Zhang H, Mehmet H, Hegde LG, Hu X, Carter LL, Aicher TD, Glick G, Zaller D, Hawwari A, Correll CC, Jones DC, Cua DJ. Guo Y, et al. Among authors: engstrom l. Cell Rep. 2016 Dec 20;17(12):3206-3218. doi: 10.1016/j.celrep.2016.11.073. Cell Rep. 2016. PMID: 28009290 Free article.
A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.
St Pierre C, Guo J, Shin JD, Engstrom LW, Lee HH, Herbert A, Surdi L, Baker J, Salmon M, Shah S, Ellis JM, Houshyar H, Crackower MA, Kleinschek MA, Jones DC, Hicks A, Zaller DM, Alves SE, Ramadas RA. St Pierre C, et al. Among authors: engstrom lw. PLoS One. 2017 Jul 18;12(7):e0180870. doi: 10.1371/journal.pone.0180870. eCollection 2017. PLoS One. 2017. PMID: 28719615 Free PMC article.
214 results