Jeng AY - Search Results

1

Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.

LaSala D, Shibanaka Y, Jeng AY. LaSala D, et al. Among authors: jeng ay. Anal Biochem. 2009 Nov 1;394(1):56-61. doi: 10.1016/j.ab.2009.07.025. Epub 2009 Jul 19. Anal Biochem. 2009. PMID: 19622340

2

Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.

Papillon JP, Adams CM, Hu QY, Lou C, Singh AK, Zhang C, Carvalho J, Rajan S, Amaral A, Beil ME, Fu F, Gangl E, Hu CW, Jeng AY, LaSala D, Liang G, Logman M, Maniara WM, Rigel DF, Smith SA, Ksander GM. Papillon JP, et al. Among authors: jeng ay. J Med Chem. 2015 Jun 11;58(11):4749-70. doi: 10.1021/acs.jmedchem.5b00407. Epub 2015 May 21. J Med Chem. 2015. PMID: 25953419

3

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.

Meredith EL, Ksander G, Monovich LG, Papillon JP, Liu Q, Miranda K, Morris P, Rao C, Burgis R, Capparelli M, Hu QY, Singh A, Rigel DF, Jeng AY, Beil M, Fu F, Hu CW, LaSala D. Meredith EL, et al. Among authors: jeng ay. ACS Med Chem Lett. 2013 Oct 17;4(12):1203-7. doi: 10.1021/ml400324c. eCollection 2013 Dec 12. ACS Med Chem Lett. 2013. PMID: 24900631 Free PMC article.

4

Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects.

Ménard J, Rigel DF, Watson C, Jeng AY, Fu F, Beil M, Liu J, Chen W, Hu CW, Leung-Chu J, LaSala D, Liang G, Rebello S, Zhang Y, Dole WP. Ménard J, et al. Among authors: jeng ay. J Transl Med. 2014 Dec 10;12:340. doi: 10.1186/s12967-014-0340-9. J Transl Med. 2014. PMID: 25491597 Free PMC article. Clinical Trial.

5

Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.

Papillon JP, Lou C, Singh AK, Adams CM, Ksander GM, Beil ME, Chen W, Leung-Chu J, Fu F, Gan L, Hu CW, Jeng AY, LaSala D, Liang G, Rigel DF, Russell KS, Vest JA, Watson C. Papillon JP, et al. Among authors: jeng ay. J Med Chem. 2015 Dec 10;58(23):9382-94. doi: 10.1021/acs.jmedchem.5b01545. Epub 2015 Nov 18. J Med Chem. 2015. PMID: 26540564

6

The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.

Adams CM, Hu CW, Jeng AY, Karki R, Ksander G, Lasala D, Leung-Chu J, Liang G, Liu Q, Meredith E, Rao C, Rigel DF, Shi J, Smith S, Springer C, Zhang C. Adams CM, et al. Among authors: jeng ay. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4324-7. doi: 10.1016/j.bmcl.2010.06.086. Epub 2010 Jun 19. Bioorg Med Chem Lett. 2010. PMID: 20615692

7

Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone.

Rigel DF, Fu F, Beil M, Hu CW, Liang G, Jeng AY. Rigel DF, et al. Among authors: jeng ay. J Pharmacol Exp Ther. 2010 Jul;334(1):232-43. doi: 10.1124/jpet.110.167148. Epub 2010 Mar 30. J Pharmacol Exp Ther. 2010. PMID: 20354176

8

Synergistic stimulation of aldosterone production in human adrenocortical carcinoma NCI-H295R cells by endothelin-1 and angiotensin II.

Hu CW, Webb RL, Jeng AY. Hu CW, et al. Among authors: jeng ay. J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S289-92. doi: 10.1097/01.fjc.0000166276.32421.1d. J Cardiovasc Pharmacol. 2004. PMID: 15838303

9

Utility of endothelin-converting enzyme inhibitors for the treatment of cardiovascular diseases.

Jeng AY. Jeng AY. Curr Opin Investig Drugs. 2003 Sep;4(9):1076-81. Curr Opin Investig Drugs. 2003. PMID: 14582451 Review.

10

Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications.

Jeng AY, Mulder P, Kwan AL, Battistini B. Jeng AY, et al. Can J Physiol Pharmacol. 2002 May;80(5):440-9. doi: 10.1139/y02-025. Can J Physiol Pharmacol. 2002. PMID: 12056551 Review.

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