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Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia.
Schimmer AD, Estey EH, Borthakur G, Carter BZ, Schiller GJ, Tallman MS, Altman JK, Karp JE, Kassis J, Hedley DW, Brandwein J, Xu W, Mak DH, LaCasse E, Jacob C, Morris SJ, Jolivet J, Andreeff M. Schimmer AD, et al. Among authors: lacasse e. J Clin Oncol. 2009 Oct 1;27(28):4741-6. doi: 10.1200/JCO.2009.21.8172. Epub 2009 Aug 3. J Clin Oncol. 2009. PMID: 19652057 Free PMC article. Clinical Trial.
Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer.
Dean E, Jodrell D, Connolly K, Danson S, Jolivet J, Durkin J, Morris S, Jowle D, Ward T, Cummings J, Dickinson G, Aarons L, Lacasse E, Robson L, Dive C, Ranson M. Dean E, et al. Among authors: lacasse e. J Clin Oncol. 2009 Apr 1;27(10):1660-6. doi: 10.1200/JCO.2008.19.5677. Epub 2009 Feb 23. J Clin Oncol. 2009. PMID: 19237630 Clinical Trial.
X-linked inhibitor of apoptosis regulates T cell effector function.
Zehntner SP, Bourbonnière L, Moore CS, Morris SJ, Methot D, St Jean M, Lacasse E, Hebb AL, Robertson GS, Durkin J, Gillard JW, Owens T. Zehntner SP, et al. Among authors: lacasse e. J Immunol. 2007 Dec 1;179(11):7553-60. doi: 10.4049/jimmunol.179.11.7553. J Immunol. 2007. PMID: 18025200
Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.
Cummings J, Ranson M, Lacasse E, Ganganagari JR, St-Jean M, Jayson G, Durkin J, Dive C. Cummings J, et al. Among authors: lacasse e. Br J Cancer. 2006 Jul 3;95(1):42-8. doi: 10.1038/sj.bjc.6603220. Br J Cancer. 2006. PMID: 16804528 Free PMC article.
76 results