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Page 1
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.
Woodrow MD, Ballantine SP, Barker MD, Clarke BJ, Dawson J, Dean TW, Delves CJ, Evans B, Gough SL, Guntrip SB, Holman S, Holmes DS, Kranz M, Lindvaal MK, Lucas FS, Neu M, Ranshaw LE, Solanke YE, Somers DO, Ward P, Wiseman JO. Woodrow MD, et al. Among authors: dean tw. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5261-5. doi: 10.1016/j.bmcl.2009.04.012. Epub 2009 Apr 9. Bioorg Med Chem Lett. 2009. PMID: 19656678
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.
Wellaway CR, Amans D, Bamborough P, Barnett H, Bit RA, Brown JA, Carlson NR, Chung CW, Cooper AWJ, Craggs PD, Davis RP, Dean TW, Evans JP, Gordon L, Harada IL, Hirst DJ, Humphreys PG, Jones KL, Lewis AJ, Lindon MJ, Lugo D, Mahmood M, McCleary S, Medeiros P, Mitchell DJ, O'Sullivan M, Le Gall A, Patel VK, Patten C, Poole DL, Shah RR, Smith JE, Stafford KAJ, Thomas PJ, Vimal M, Wall ID, Watson RJ, Wellaway N, Yao G, Prinjha RK. Wellaway CR, et al. Among authors: dean tw. J Med Chem. 2020 Jan 23;63(2):714-746. doi: 10.1021/acs.jmedchem.9b01670. Epub 2020 Jan 6. J Med Chem. 2020. PMID: 31904959
Nuisance Compounds, PAINS Filters, and Dark Chemical Matter in the GSK HTS Collection.
Chakravorty SJ, Chan J, Greenwood MN, Popa-Burke I, Remlinger KS, Pickett SD, Green DVS, Fillmore MC, Dean TW, Luengo JI, Macarrón R. Chakravorty SJ, et al. Among authors: dean tw. SLAS Discov. 2018 Jul;23(6):532-545. doi: 10.1177/2472555218768497. Epub 2018 Apr 26. SLAS Discov. 2018. PMID: 29699447 Free article.
Pharmacological properties of acid N-thiazolylamide FFA2 agonists.
Brown AJ, Tsoulou C, Ward E, Gower E, Bhudia N, Chowdhury F, Dean TW, Faucher N, Gangar A, Dowell SJ. Brown AJ, et al. Among authors: dean tw. Pharmacol Res Perspect. 2015 Jun;3(3):e00141. doi: 10.1002/prp2.141. Epub 2015 May 8. Pharmacol Res Perspect. 2015. PMID: 26236484 Free PMC article.
Self-indicating amine scavenger resins.
Cho JK, White PD, Klute W, Dean TW, Bradley M. Cho JK, et al. Among authors: dean tw. Chem Commun (Camb). 2004 Mar 7;(5):502-3. doi: 10.1039/b315426b. Epub 2004 Jan 27. Chem Commun (Camb). 2004. PMID: 14973578
pH indicating resins.
Cho JK, Wong LS, Dean TW, Ichihara O, Muller C, Bradley M. Cho JK, et al. Among authors: dean tw. Chem Commun (Camb). 2004 Jul 7;(13):1470-1. doi: 10.1039/b405198j. Epub 2004 May 25. Chem Commun (Camb). 2004. PMID: 15216335
Captured and cross-linked palladium nanoparticles.
Cho JK, Najman R, Dean TW, Ichihara O, Muller C, Bradley M. Cho JK, et al. Among authors: dean tw. J Am Chem Soc. 2006 May 17;128(19):6276-7. doi: 10.1021/ja057480k. J Am Chem Soc. 2006. PMID: 16683766
38 results