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Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes.
LaVallie ER, Chockalingam PS, Collins-Racie LA, Freeman BA, Keohan CC, Leitges M, Dorner AJ, Morris EA, Majumdar MK, Arai M. LaVallie ER, et al. J Biol Chem. 2006 Aug 25;281(34):24124-37. doi: 10.1074/jbc.M601905200. Epub 2006 Jun 23. J Biol Chem. 2006. PMID: 16798739 Free article.
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD. Westling J, et al. Among authors: lavallie er. J Biol Chem. 2002 May 3;277(18):16059-66. doi: 10.1074/jbc.M108607200. Epub 2002 Feb 19. J Biol Chem. 2002. PMID: 11854269 Free article.
Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system.
Arai M, Anderson D, Kurdi Y, Annis-Freeman B, Shields K, Collins-Racie LA, Corcoran C, DiBlasio-Smith E, Pittman DD, Dorner AJ, Morris E, LaVallie ER. Arai M, et al. Among authors: lavallie er. Osteoarthritis Cartilage. 2004 Aug;12(8):599-613. doi: 10.1016/j.joca.2004.05.001. Osteoarthritis Cartilage. 2004. PMID: 15262240 Free article.
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.
Collins-Racie LA, Flannery CR, Zeng W, Corcoran C, Annis-Freeman B, Agostino MJ, Arai M, DiBlasio-Smith E, Dorner AJ, Georgiadis KE, Jin M, Tan XY, Morris EA, LaVallie ER. Collins-Racie LA, et al. Among authors: lavallie er. Matrix Biol. 2004 Jul;23(4):219-30. doi: 10.1016/j.matbio.2004.05.004. Matrix Biol. 2004. PMID: 15296936
LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model.
Li N, Rivéra-Bermúdez MA, Zhang M, Tejada J, Glasson SS, Collins-Racie LA, Lavallie ER, Wang Y, Chang KC, Nagpal S, Morris EA, Flannery CR, Yang Z. Li N, et al. Among authors: lavallie er. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3734-9. doi: 10.1073/pnas.0911377107. Epub 2010 Feb 3. Proc Natl Acad Sci U S A. 2010. PMID: 20133709 Free PMC article.
62 results