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Structure-Based Design of Anticancer Prodrug PABA/NO.
Ji X, Pal A, Kalathur R, Hu X, Gu Y, Saavedra JE, Buzard GS, Srinivasan A, Keefer LK, Singh SV. Ji X, et al. Among authors: keefer lk. Drug Des Devel Ther. 2008;2:123-130. doi: 10.2147/dddt.s3931. Drug Des Devel Ther. 2008. PMID: 19662104 Free PMC article.
PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity.
Saavedra JE, Srinivasan A, Buzard GS, Davies KM, Waterhouse DJ, Inami K, Wilde TC, Citro ML, Cuellar M, Deschamps JR, Parrish D, Shami PJ, Findlay VJ, Townsend DM, Tew KD, Singh S, Jia L, Ji X, Keefer LK. Saavedra JE, et al. Among authors: keefer lk. J Med Chem. 2006 Feb 9;49(3):1157-64. doi: 10.1021/jm050700k. J Med Chem. 2006. PMID: 16451080 Free PMC article.
V-PROLI/NO, a prodrug of the nitric oxide donor, PROLI/NO.
Chakrapani H, Showalter BM, Kong L, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: keefer lk. Org Lett. 2007 Aug 16;9(17):3409-12. doi: 10.1021/ol701419a. Epub 2007 Jul 20. Org Lett. 2007. PMID: 17658755
The Nitric Oxide Prodrug V-PROLI/NO Inhibits Cellular Uptake of Proline.
Hong SY, Borchert GL, Maciag AE, Nandurdikar RS, Saavedra JE, Keefer LK, Phang JM, Chakrapani H. Hong SY, et al. Among authors: keefer lk. ACS Med Chem Lett. 2010 Nov 11;1(8):386-389. doi: 10.1021/ml1000905. ACS Med Chem Lett. 2010. PMID: 21212855 Free PMC article.
245 results