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Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.
Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J. Albuquerque RJ, et al. Among authors: hirashima m. Nat Med. 2009 Sep;15(9):1023-30. doi: 10.1038/nm.2018. Epub 2009 Aug 9. Nat Med. 2009. PMID: 19668192 Free PMC article.
Blood and lymphatic systems are segregated by the FLCN tumor suppressor.
Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Liu C, Li W, Mukouyama YS, Marston Linehan W, Liu X, Hirashima M, Suzuki Y, Funasaki S, Satou Y, Furuya M, Baba M, Kubota Y. Tai-Nagara I, et al. Among authors: hirashima m. Nat Commun. 2020 Dec 9;11(1):6314. doi: 10.1038/s41467-020-20156-6. Nat Commun. 2020. PMID: 33298956 Free PMC article.
Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells.
Osada M, Inoue O, Ding G, Shirai T, Ichise H, Hirayama K, Takano K, Yatomi Y, Hirashima M, Fujii H, Suzuki-Inoue K, Ozaki Y. Osada M, et al. Among authors: hirashima m. J Biol Chem. 2012 Jun 22;287(26):22241-52. doi: 10.1074/jbc.M111.329987. Epub 2012 May 3. J Biol Chem. 2012. PMID: 22556408 Free PMC article.
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown.
Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro-Oonuma T, Hwang Y, Ahn S, Park I, Ikeda W, Kusuhara S, Fukushima Y, Nara H, Sakai H, Fujiwara T, Matsushita J, Ema M, Hirashima M, Minami T, Shibuya M, Takakura N, Kim P, Miyata T, Ogura Y, Uemura A. Ogura S, et al. Among authors: hirashima m. JCI Insight. 2017 Feb 9;2(3):e90905. doi: 10.1172/jci.insight.90905. JCI Insight. 2017. PMID: 28194443 Free PMC article.
363 results