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The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response.
Zelinskyy G, Dietze KK, Hüsecken YP, Schimmer S, Nair S, Werner T, Gibbert K, Kershaw O, Gruber AD, Sparwasser T, Dittmer U. Zelinskyy G, et al. Among authors: dietze kk. Blood. 2009 Oct 8;114(15):3199-207. doi: 10.1182/blood-2009-03-208736. Epub 2009 Aug 11. Blood. 2009. PMID: 19671923 Free article.
Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication.
Zelinskyy G, Myers L, Dietze KK, Gibbert K, Roggendorf M, Liu J, Lu M, Kraft AR, Teichgräber V, Hasenkrug KJ, Dittmer U. Zelinskyy G, et al. Among authors: dietze kk. J Immunol. 2011 Oct 1;187(7):3730-7. doi: 10.4049/jimmunol.1101612. Epub 2011 Aug 26. J Immunol. 2011. PMID: 21873525 Free PMC article.
Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology.
David P, Drabczyk-Pluta M, Pastille E, Knuschke T, Werner T, Honke N, Megger DA, Akhmetzyanova I, Shaabani N, Eyking-Singer A, Cario E, Kershaw O, Gruber AD, Tenbusch M, Dietze KK, Trilling M, Liu J, Schadendorf D, Streeck H, Lang KS, Xie Y, Zimmer L, Sitek B, Paschen A, Westendorf AM, Dittmer U, Zelinskyy G. David P, et al. Among authors: dietze kk. PLoS Pathog. 2020 Mar 30;16(3):e1008340. doi: 10.1371/journal.ppat.1008340. eCollection 2020 Mar. PLoS Pathog. 2020. PMID: 32226027 Free PMC article.
18 results