Polyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression.
Lin J, Goto Y, Murata H, Sakaizawa K, Uchiyama A, Saida T, Takata M.
Lin J, et al.
Br J Cancer. 2011 Feb 1;104(3):464-8. doi: 10.1038/sj.bjc.6606072. Epub 2011 Jan 11.
Br J Cancer. 2011.
PMID: 21224857
Free PMC article.
BACKGROUND: Oncogenic BRAF mutation had been considered to be a founder event in the formation of melanocytic tumours; however, we recently argued against this notion by showing marked polyclonality of BRAF mutations in acquired melanocytic nevi (Lin et al, J Natl C …
BACKGROUND: Oncogenic BRAF mutation had been considered to be a founder event in the formation of melanocytic tumours; however, we recently …