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662 results

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Page 1
Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.
Takahashi H, Haga Y, Shibata T, Nonoshita K, Sakamoto T, Moriya M, Ohe T, Chiba M, Mitobe Y, Kitazawa H, Iwaasa H, Ishihara A, Ishii Y, Kanatani A, Fukami T. Takahashi H, et al. Among authors: fukami t. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5436-9. doi: 10.1016/j.bmcl.2009.07.103. Epub 2009 Jul 25. Bioorg Med Chem Lett. 2009. PMID: 19679469
(9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist.
Sato N, Jitsuoka M, Shibata T, Hirohashi T, Nonoshita K, Moriya M, Haga Y, Sakuraba A, Ando M, Ohe T, Iwaasa H, Gomori A, Ishihara A, Kanatani A, Fukami T. Sato N, et al. Among authors: fukami t. J Med Chem. 2008 Aug 14;51(15):4765-70. doi: 10.1021/jm8003587. Epub 2008 Jul 19. J Med Chem. 2008. PMID: 18637668
Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.
Ogino Y, Ohtake N, Nagae Y, Matsuda K, Moriya M, Suga T, Ishikawa M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T. Ogino Y, et al. Among authors: fukami t. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5010-4. doi: 10.1016/j.bmcl.2008.08.018. Epub 2008 Aug 12. Bioorg Med Chem Lett. 2008. PMID: 18723347
Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists.
Ogino Y, Ohtake N, Nagae Y, Matsuda K, Ishikawa M, Moriya M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T. Ogino Y, et al. Among authors: fukami t. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4997-5001. doi: 10.1016/j.bmcl.2008.08.021. Epub 2008 Aug 13. Bioorg Med Chem Lett. 2008. PMID: 18752943
Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.
Sakamoto T, Moriya M, Haga Y, Takahashi T, Shibata T, Okamoto O, Nonoshita K, Kitazawa H, Hidaka M, Gomori A, Iwaasa H, Ishihara A, Kanatani A, Fukami T, Gao YD, Macneil DJ, Yang L. Sakamoto T, et al. Among authors: fukami t. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1564-8. doi: 10.1016/j.bmcl.2009.02.035. Epub 2009 Feb 12. Bioorg Med Chem Lett. 2009. PMID: 19243937
Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.
Suzuki T, Moriya M, Sakamoto T, Suga T, Kishino H, Takahashi H, Ishikawa M, Nagai K, Imai Y, Sekino E, Ito M, Iwaasa H, Ishihara A, Tokita S, Kanatani A, Sato N, Fukami T. Suzuki T, et al. Among authors: fukami t. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3072-7. doi: 10.1016/j.bmcl.2009.04.016. Epub 2009 Apr 9. Bioorg Med Chem Lett. 2009. PMID: 19403308
662 results