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486 results

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Page 1
Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.
Takahashi H, Haga Y, Shibata T, Nonoshita K, Sakamoto T, Moriya M, Ohe T, Chiba M, Mitobe Y, Kitazawa H, Iwaasa H, Ishihara A, Ishii Y, Kanatani A, Fukami T. Takahashi H, et al. Among authors: kitazawa h. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5436-9. doi: 10.1016/j.bmcl.2009.07.103. Epub 2009 Jul 25. Bioorg Med Chem Lett. 2009. PMID: 19679469
Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.
Sakamoto T, Moriya M, Haga Y, Takahashi T, Shibata T, Okamoto O, Nonoshita K, Kitazawa H, Hidaka M, Gomori A, Iwaasa H, Ishihara A, Kanatani A, Fukami T, Gao YD, Macneil DJ, Yang L. Sakamoto T, et al. Among authors: kitazawa h. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1564-8. doi: 10.1016/j.bmcl.2009.02.035. Epub 2009 Feb 12. Bioorg Med Chem Lett. 2009. PMID: 19243937
Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect.
Sato N, Ando M, Ishikawa S, Jitsuoka M, Nagai K, Takahashi H, Sakuraba A, Tsuge H, Kitazawa H, Iwaasa H, Mashiko S, Gomori A, Moriya R, Fujino N, Ohe T, Ishihara A, Kanatani A, Fukami T. Sato N, et al. Among authors: kitazawa h. J Med Chem. 2009 May 28;52(10):3385-96. doi: 10.1021/jm900110t. J Med Chem. 2009. PMID: 19459652
Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.
Haga Y, Sakamoto T, Shibata T, Nonoshita K, Ishikawa M, Suga T, Takahashi H, Takahashi T, Takahashi H, Ando M, Murai T, Gomori A, Oda Z, Kitazawa H, Mitobe Y, Kanesaka M, Ohe T, Iwaasa H, Ishii Y, Ishihara A, Kanatani A, Fukami T. Haga Y, et al. Among authors: kitazawa h. Bioorg Med Chem. 2009 Oct 1;17(19):6971-82. doi: 10.1016/j.bmc.2009.08.019. Epub 2009 Aug 14. Bioorg Med Chem. 2009. PMID: 19720539
Effects of a novel Y5 antagonist in obese mice: combination with food restriction or sibutramine.
Mashiko S, Ishihara A, Iwaasa H, Moriya R, Kitazawa H, Mitobe Y, Ito J, Gomori A, Matsushita H, Takahashi T, MacNeil DJ, Van der Ploeg LH, Fukami T, Kanatani A. Mashiko S, et al. Among authors: kitazawa h. Obesity (Silver Spring). 2008 Jul;16(7):1510-5. doi: 10.1038/oby.2008.223. Epub 2008 Apr 10. Obesity (Silver Spring). 2008. PMID: 18421274 Free article.
(-)-Ternatin inhibits adipogenesis and lipid metabolism in 3T3-L1 cells.
Ito M, Ito J, Kitazawa H, Shimamura K, Fukami T, Tokita S, Shimokawa K, Yamada K, Kanatani A, Uemura D. Ito M, et al. Among authors: kitazawa h. Peptides. 2009 Jun;30(6):1074-81. doi: 10.1016/j.peptides.2009.02.008. Epub 2009 Feb 21. Peptides. 2009. PMID: 19463739
5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool.
Shimamura K, Kitazawa H, Miyamoto Y, Kanesaka M, Nagumo A, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S. Shimamura K, et al. Among authors: kitazawa h. J Pharmacol Exp Ther. 2009 Jul;330(1):249-56. doi: 10.1124/jpet.109.150854. Epub 2009 Apr 9. J Pharmacol Exp Ther. 2009. PMID: 19359527
486 results