Hamel E - Search Results

1

E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes.

Pettit RK, Pettit GR, Hamel E, Hogan F, Moser BR, Wolf S, Pon S, Chapuis JC, Schmidt JM. Pettit RK, et al. Among authors: hamel e. Bioorg Med Chem. 2009 Sep 15;17(18):6606-12. doi: 10.1016/j.bmc.2009.07.076. Epub 2009 Aug 4. Bioorg Med Chem. 2009. PMID: 19709889

2

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.

Getahun Z, Jurd L, Chu PS, Lin CM, Hamel E. Getahun Z, et al. Among authors: hamel e. J Med Chem. 1992 Mar 20;35(6):1058-67. doi: 10.1021/jm00084a011. J Med Chem. 1992. PMID: 1552500

3

Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.

Cushman M, Nagarathnam D, Gopal D, He HM, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1992 Jun 12;35(12):2293-306. doi: 10.1021/jm00090a021. J Med Chem. 1992. PMID: 1613753

4

Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.

Bai R, Friedman SJ, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Biochem Pharmacol. 1992 Jun 23;43(12):2637-45. doi: 10.1016/0006-2952(92)90153-a. Biochem Pharmacol. 1992. PMID: 1632820

5

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. J Biol Chem. 1991 Aug 25;266(24):15882-9. J Biol Chem. 1991. PMID: 1874739 Free article.

6

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

Cushman M, Nagarathnam D, Gopal D, Chakraborti AK, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1991 Aug;34(8):2579-88. doi: 10.1021/jm00112a036. J Med Chem. 1991. PMID: 1875350

7

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

Bai RL, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. J Biol Chem. 1990 Oct 5;265(28):17141-9. J Biol Chem. 1990. PMID: 2211617 Free article.

8

Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.

Bai RL, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. Biochem Pharmacol. 1990 Oct 15;40(8):1859-64. doi: 10.1016/0006-2952(90)90367-t. Biochem Pharmacol. 1990. PMID: 2242019

9

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.

Bai R, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Biochem Pharmacol. 1990 Jun 15;39(12):1941-9. doi: 10.1016/0006-2952(90)90613-p. Biochem Pharmacol. 1990. PMID: 2353935

10

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin.

Lin CM, Ho HH, Pettit GR, Hamel E. Lin CM, et al. Among authors: hamel e. Biochemistry. 1989 Aug 22;28(17):6984-91. doi: 10.1021/bi00443a031. Biochemistry. 1989. PMID: 2819042

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