Steffan JS - Search Results

1

Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.

Aiken CT, Steffan JS, Guerrero CM, Khashwji H, Lukacsovich T, Simmons D, Purcell JM, Menhaji K, Zhu YZ, Green K, Laferla F, Huang L, Thompson LM, Marsh JL. Aiken CT, et al. Among authors: steffan js. J Biol Chem. 2009 Oct 23;284(43):29427-36. doi: 10.1074/jbc.M109.013193. Epub 2009 Aug 26. J Biol Chem. 2009. PMID: 19710014 Free PMC article.

2

Gene sequence and primary structure of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae.

Thompson LM, Sutherland P, Steffan JS, McAlister-Henn L. Thompson LM, et al. Among authors: steffan js. Biochemistry. 1988 Nov 1;27(22):8393-400. doi: 10.1021/bi00422a015. Biochemistry. 1988. PMID: 3072021

3

RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I.

Lalo D, Steffan JS, Dodd JA, Nomura M. Lalo D, et al. Among authors: steffan js. J Biol Chem. 1996 Aug 30;271(35):21062-7. doi: 10.1074/jbc.271.35.21062. J Biol Chem. 1996. PMID: 8702872 Free article.

4

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H, Wanker EE, Bates GP, Housman DE, Thompson LM. Steffan JS, et al. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6763-8. doi: 10.1073/pnas.100110097. Proc Natl Acad Sci U S A. 2000. PMID: 10823891 Free PMC article.

5

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM. Steffan JS, et al. Nature. 2001 Oct 18;413(6857):739-43. doi: 10.1038/35099568. Nature. 2001. PMID: 11607033

6

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.

Kazantsev A, Walker HA, Slepko N, Bear JE, Preisinger E, Steffan JS, Zhu YZ, Gertler FB, Housman DE, Marsh JL, Thompson LM. Kazantsev A, et al. Among authors: steffan js. Nat Genet. 2002 Apr;30(4):367-76. doi: 10.1038/ng864. Epub 2002 Mar 25. Nat Genet. 2002. PMID: 11925563

7

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.

Hockly E, Richon VM, Woodman B, Smith DL, Zhou X, Rosa E, Sathasivam K, Ghazi-Noori S, Mahal A, Lowden PA, Steffan JS, Marsh JL, Thompson LM, Lewis CM, Marks PA, Bates GP. Hockly E, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2041-6. doi: 10.1073/pnas.0437870100. Epub 2003 Feb 7. Proc Natl Acad Sci U S A. 2003. PMID: 12576549 Free PMC article.

8

Targeting aggregation in the development of therapeutics for the treatment of Huntington's disease and other polyglutamine repeat diseases.

Steffan JS, Thompson LM. Steffan JS, et al. Expert Opin Ther Targets. 2003 Apr;7(2):201-13. doi: 10.1517/14728222.7.2.201. Expert Opin Ther Targets. 2003. PMID: 12667098 Review.

9

SUMO modification of Huntingtin and Huntington's disease pathology.

Steffan JS, Agrawal N, Pallos J, Rockabrand E, Trotman LC, Slepko N, Illes K, Lukacsovich T, Zhu YZ, Cattaneo E, Pandolfi PP, Thompson LM, Marsh JL. Steffan JS, et al. Science. 2004 Apr 2;304(5667):100-4. doi: 10.1126/science.1092194. Science. 2004. PMID: 15064418

10

Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins.

Slepko N, Bhattacharyya AM, Jackson GR, Steffan JS, Marsh JL, Thompson LM, Wetzel R. Slepko N, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14367-72. doi: 10.1073/pnas.0602348103. Epub 2006 Sep 15. Proc Natl Acad Sci U S A. 2006. PMID: 16980414 Free PMC article.

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