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Page 1
Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.
Zhou D, Stack GP, Lo J, Failli AA, Evrard DA, Harrison BL, Hatzenbuhler NT, Tran M, Croce S, Yi S, Golembieski J, Hornby GA, Lai M, Lin Q, Schechter LE, Smith DL, Shilling AD, Huselton C, Mitchell P, Beyer CE, Andree TH. Zhou D, et al. Among authors: hornby ga. J Med Chem. 2009 Aug 13;52(15):4955-9. doi: 10.1021/jm900374r. J Med Chem. 2009. PMID: 19719241
Preclinical characterization of WAY-211612: a dual 5-HT uptake inhibitor and 5-HT (1A) receptor antagonist and potential novel antidepressant.
Beyer CE, Lin Q, Platt B, Malberg J, Hornby G, Sullivan KM, Smith DL, Lock T, Mitchell PJ, Hatzenbuhler NT, Evrard DA, Harrison BL, Magolda R, Pangalos MN, Schechter LE, Rosenzweig-Lipson S, Andree TH. Beyer CE, et al. Br J Pharmacol. 2009 May;157(2):307-19. doi: 10.1111/j.1476-5381.2009.00146.x. Epub 2009 Mar 26. Br J Pharmacol. 2009. PMID: 19338583 Free PMC article.
Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor.
Evrard DA, Zhou P, Yi SY, Zhou D, Smith DL, Sullivan KM, Hornby GA, Schechter LE, Andree TH, Mewshaw RE. Evrard DA, et al. Among authors: hornby ga. Bioorg Med Chem Lett. 2005 Feb 15;15(4):911-4. doi: 10.1016/j.bmcl.2004.12.064. Bioorg Med Chem Lett. 2005. PMID: 15686885
Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
Zhou D, Harrison BL, Shah U, Andree TH, Hornby GA, Scerni R, Schechter LE, Smith DL, Sullivan KM, Mewshaw RE. Zhou D, et al. Among authors: hornby ga. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1338-41. doi: 10.1016/j.bmcl.2005.11.054. Epub 2005 Dec 5. Bioorg Med Chem Lett. 2006. PMID: 16332439
Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.
Zhou D, Zhou P, Evrard DA, Meagher K, Webb M, Harrison BL, Huryn DM, Golembieski J, Hornby GA, Schechter LE, Smith DL, Andree TH, Mewshaw RE. Zhou D, et al. Among authors: hornby ga. Bioorg Med Chem. 2008 Jul 15;16(14):6707-23. doi: 10.1016/j.bmc.2008.05.075. Epub 2008 Jun 5. Bioorg Med Chem. 2008. PMID: 18571421
Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
Hatzenbuhler NT, Evrard DA, Harrison BL, Huryn D, Inghrim J, Kraml C, Mattes JF, Mewshaw RE, Zhou D, Hornby G, Lin Q, Smith DL, Sullivan KM, Schechter LE, Beyer CE, Andree TH. Hatzenbuhler NT, et al. J Med Chem. 2006 Jul 27;49(15):4785-9. doi: 10.1021/jm060218h. J Med Chem. 2006. PMID: 16854086
15 results