Malik P - Search Results

1

The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity.

Arumugam PI, Urbinati F, Velu CS, Higashimoto T, Grimes HL, Malik P. Arumugam PI, et al. Among authors: malik p. PLoS One. 2009 Sep 10;4(9):e6995. doi: 10.1371/journal.pone.0006995. PLoS One. 2009. PMID: 19746166 Free PMC article.

2

Gene Therapy for beta-thalassemia.

Malik P, Arumugam PI. Malik P, et al. Hematology Am Soc Hematol Educ Program. 2005:45-50. doi: 10.1182/asheducation-2005.1.45. Hematology Am Soc Hematol Educ Program. 2005. PMID: 16304358

3

Successful correction of the human Cooley's anemia beta-thalassemia major phenotype using a lentiviral vector flanked by the chicken hypersensitive site 4 chromatin insulator.

Malik P, Arumugam PI, Yee JK, Puthenveetil G. Malik P, et al. Ann N Y Acad Sci. 2005;1054:238-49. doi: 10.1196/annals.1345.030. Ann N Y Acad Sci. 2005. PMID: 16339671 Review.

4

Pathophysiology and therapy for haemoglobinopathies. Part II: thalassaemias.

Urbinati F, Madigan C, Malik P. Urbinati F, et al. Among authors: malik p. Expert Rev Mol Med. 2006 May 9;8(10):1-26. doi: 10.1017/S1462399406010805. Expert Rev Mol Med. 2006. PMID: 16684395 Review.

5

The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors.

Higashimoto T, Urbinati F, Perumbeti A, Jiang G, Zarzuela A, Chang LJ, Kohn DB, Malik P. Higashimoto T, et al. Among authors: malik p. Gene Ther. 2007 Sep;14(17):1298-304. doi: 10.1038/sj.gt.3302979. Epub 2007 Jun 28. Gene Ther. 2007. PMID: 17597793

6

Improved human beta-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element.

Arumugam PI, Scholes J, Perelman N, Xia P, Yee JK, Malik P. Arumugam PI, et al. Among authors: malik p. Mol Ther. 2007 Oct;15(10):1863-71. doi: 10.1038/sj.mt.6300259. Epub 2007 Jul 10. Mol Ther. 2007. PMID: 17622240 Free article.

7

Mechanism of reduction in titers from lentivirus vectors carrying large inserts in the 3'LTR.

Urbinati F, Arumugam P, Higashimoto T, Perumbeti A, Mitts K, Xia P, Malik P. Urbinati F, et al. Among authors: malik p. Mol Ther. 2009 Sep;17(9):1527-36. doi: 10.1038/mt.2009.89. Epub 2009 Apr 21. Mol Ther. 2009. PMID: 19384292 Free PMC article.

8

A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction.

Perumbeti A, Higashimoto T, Urbinati F, Franco R, Meiselman HJ, Witte D, Malik P. Perumbeti A, et al. Among authors: malik p. Blood. 2009 Aug 6;114(6):1174-85. doi: 10.1182/blood-2009-01-201863. Epub 2009 May 27. Blood. 2009. PMID: 19474450 Free PMC article.

9

Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.

Arumugam PI, Higashimoto T, Urbinati F, Modlich U, Nestheide S, Xia P, Fox C, Corsinotti A, Baum C, Malik P. Arumugam PI, et al. Among authors: malik p. Mol Ther. 2009 Nov;17(11):1929-37. doi: 10.1038/mt.2009.183. Epub 2009 Aug 25. Mol Ther. 2009. PMID: 19707188 Free PMC article.

10

Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome.

Wang D, Zhang W, Kalfa TA, Grabowski G, Davies S, Malik P, Pan D. Wang D, et al. Among authors: malik p. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19958-63. doi: 10.1073/pnas.0908528106. Epub 2009 Nov 10. Proc Natl Acad Sci U S A. 2009. PMID: 19903883 Free PMC article.

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