Kleanthous C - Search Results

1

Following evolutionary paths to protein-protein interactions with high affinity and selectivity.

Levin KB, Dym O, Albeck S, Magdassi S, Keeble AH, Kleanthous C, Tawfik DS. Levin KB, et al. Among authors: kleanthous c. Nat Struct Mol Biol. 2009 Oct;16(10):1049-55. doi: 10.1038/nsmb.1670. Epub 2009 Sep 13. Nat Struct Mol Biol. 2009. PMID: 19749752

2

The cytotoxic domain of colicin E9 is a channel-forming endonuclease.

Mosbahi K, Lemaître C, Keeble AH, Mobasheri H, Morel B, James R, Moore GR, Lea EJ, Kleanthous C. Mosbahi K, et al. Among authors: kleanthous c. Nat Struct Biol. 2002 Jun;9(6):476-84. doi: 10.1038/nsb797. Nat Struct Biol. 2002. PMID: 12021774 Free article.

3

Highly discriminating protein-protein interaction specificities in the context of a conserved binding energy hotspot.

Li W, Keeble AH, Giffard C, James R, Moore GR, Kleanthous C. Li W, et al. Among authors: kleanthous c. J Mol Biol. 2004 Mar 26;337(3):743-59. doi: 10.1016/j.jmb.2004.02.005. J Mol Biol. 2004. PMID: 15019791

4

The kinetic basis for dual recognition in colicin endonuclease-immunity protein complexes.

Keeble AH, Kleanthous C. Keeble AH, et al. Among authors: kleanthous c. J Mol Biol. 2005 Sep 23;352(3):656-71. doi: 10.1016/j.jmb.2005.07.035. J Mol Biol. 2005. PMID: 16109424

5

Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases.

Keeble AH, Joachimiak LA, Maté MJ, Meenan N, Kirkpatrick N, Baker D, Kleanthous C. Keeble AH, et al. Among authors: kleanthous c. J Mol Biol. 2008 Jun 13;379(4):745-59. doi: 10.1016/j.jmb.2008.03.055. Epub 2008 Apr 3. J Mol Biol. 2008. PMID: 18471830

6

Ultrahigh specificity in a network of computationally designed protein-interaction pairs.

Netzer R, Listov D, Lipsh R, Dym O, Albeck S, Knop O, Kleanthous C, Fleishman SJ. Netzer R, et al. Among authors: kleanthous c. Nat Commun. 2018 Dec 11;9(1):5286. doi: 10.1038/s41467-018-07722-9. Nat Commun. 2018. PMID: 30538236 Free PMC article.

7

Multistep binding of transition metals to the H-N-H endonuclease toxin colicin E9.

Keeble AH, Hemmings AM, James R, Moore GR, Kleanthous C. Keeble AH, et al. Among authors: kleanthous c. Biochemistry. 2002 Aug 13;41(32):10234-44. doi: 10.1021/bi020174o. Biochemistry. 2002. PMID: 12162738

8

Calorimetric dissection of colicin DNase--immunity protein complex specificity.

Keeble AH, Kirkpatrick N, Shimizu S, Kleanthous C. Keeble AH, et al. Among authors: kleanthous c. Biochemistry. 2006 Mar 14;45(10):3243-54. doi: 10.1021/bi052373o. Biochemistry. 2006. PMID: 16519519

9

Mechanism and cleavage specificity of the H-N-H endonuclease colicin E9.

Pommer AJ, Cal S, Keeble AH, Walker D, Evans SJ, Kühlmann UC, Cooper A, Connolly BA, Hemmings AM, Moore GR, James R, Kleanthous C. Pommer AJ, et al. Among authors: kleanthous c. J Mol Biol. 2001 Dec 7;314(4):735-49. doi: 10.1006/jmbi.2001.5189. J Mol Biol. 2001. PMID: 11733993

10

Ligand-induced changes in the conformational dynamics of a bacterial cytotoxic endonuclease.

van den Bremer ET, Keeble AH, Visser AJ, van Hoek A, Kleanthous C, Heck AJ, Jiskoot W. van den Bremer ET, et al. Among authors: kleanthous c. Biochemistry. 2004 Apr 13;43(14):4347-55. doi: 10.1021/bi049929c. Biochemistry. 2004. PMID: 15065879

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